{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:42:40Z","timestamp":1790404960655,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Vaccine Research Institute, Investissement d'Avenir program managed by the ANR, France","award":["ANR-10-LABX-77-01"],"award-info":[{"award-number":["ANR-10-LABX-77-01"]}]},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2021,4,12]]},"abstract":"<jats:p>In this placebo-controlled phase II randomized clinical trial, we evaluated the safety and immunogenicity of a therapeutic prime-boost vaccine strategy using a recombinant DNA vaccine (GTU-MultiHIV B clade) followed by a boost vaccination with a lipopeptide vaccine (HIV-LIPO-5) in HIV-infected patients on combined antiretroviral therapy. We show here that this prime-boost strategy is well tolerated, consistently with previous studies in HIV-1-infected individuals and healthy volunteers who received each vaccine component individually.<\/jats:p>","DOI":"10.1128\/jvi.02165-20","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T09:03:17Z","timestamp":1612774997000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["A Randomized Placebo-Controlled Efficacy Study of a Prime Boost Therapeutic Vaccination Strategy in HIV-1-Infected Individuals: VRI02 ANRS 149 LIGHT Phase II Trial"],"prefix":"10.1128","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5549-6256","authenticated-orcid":true,"given":"Y.","family":"L\u00e9vy","sequence":"first","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S 955, Cr\u00e9teil, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Groupe Henri-Mondor Albert-Chenevier, Service d\u2019Immunologie clinique, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lacabaratz","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S 955, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lhomme","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"University of Bordeaux, Department of Public Health, Inserm Bordeaux Population Health Research Centre, Inria SISTM, Bordeaux, France"},{"name":"P\u00f4le de Sant\u00e9 Publique, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S 955, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bauduin","sequence":"additional","affiliation":[{"name":"University of Bordeaux, ISPED, Inserm, Population Health Research Center, Team MORPH3EUS, UMR 1219, CIC-EC 1401, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-0110","authenticated-orcid":true,"given":"C.","family":"Fenwick","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Foucat","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S 955, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Surenaud","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S 955, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Guillaumat","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S 955, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Boilet","sequence":"additional","affiliation":[{"name":"University of Bordeaux, ISPED, Inserm, Population Health Research Center, Team MORPH3EUS, UMR 1219, CIC-EC 1401, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rieux","sequence":"additional","affiliation":[{"name":"Inserm-ANRS, Vaccine Research Office, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Bouchaud","sequence":"additional","affiliation":[{"name":"H\u00f4pital Avicenne, AP-HP, Universit\u00e9 Paris 13, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.-M.","family":"Girard","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Antoine, AP-HP, INSERM UMR S_1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-M.","family":"Molina","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Diderot INSERM U941, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Morlat","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hocqueloux","sequence":"additional","affiliation":[{"name":"CHR d\u2019Orl\u00e9ans, La Source, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Richert","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"University of Bordeaux, Department of Public Health, Inserm Bordeaux Population Health Research Centre, Inria SISTM, Bordeaux, France"},{"name":"P\u00f4le de Sant\u00e9 Publique, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-2721","authenticated-orcid":true,"given":"G.","family":"Pantaleo","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Leli\u00e8vre","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S 955, Cr\u00e9teil, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Groupe Henri-Mondor Albert-Chenevier, Service d\u2019Immunologie clinique, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Thi\u00e9baut,","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"University of Bordeaux, Department of Public Health, Inserm Bordeaux Population Health Research Centre, Inria SISTM, Bordeaux, France"},{"name":"P\u00f4le de Sant\u00e9 Publique, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3550"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6517"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000324"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000491"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02911"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833ce566"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835f5b60"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw2607"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30052-9"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz012"},{"key":"e_1_3_2_13_2","first-page":"279","article-title":"Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients","volume":"19","author":"L\u00e9vy Y","year":"2005","unstructured":"L\u00e9vy Y, Gah\u00e9ry-S\u00e9gard H, Durier C, Lascaux AS, Goujard C, Meiffr\u00e9dy V, Rouzioux C, El Habib R, Beumont-Mauviel M, Guillet JG, Delfraissy JF, Aboulker JP. 2005. Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients. AIDS 19:279\u2013286.","journal-title":"AIDS"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2007.0047"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002058"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000206504.09159.d3"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344433"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1374182"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008011"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-4818"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.10.018"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80445"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005349"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611244104"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00874"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.12.008"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621489114"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax3447"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz036"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30082-7"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02165-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02165-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T10:08:24Z","timestamp":1646474904000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02165-20"}},"subtitle":[],"editor":[{"given":"Guido","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,12]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,4,12]]}},"alternative-id":["10.1128\/JVI.02165-20"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02165-20","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,12]]},"assertion":[{"value":"2020-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02165-20"}}