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IAV are known to modulate cellular pathways to promote their replication and avoid immune restriction via the targeting of several cellular proteins. One of these proteins, p53, is a master regulator involved in a large panel of biological processes, including cell cycle arrest, apoptosis, or senescence. This \u201ccellular gatekeeper\u201d is also involved in the control of viral infections, and viruses have developed a wide diversity of mechanisms to modulate\/hijack p53 functions to achieve an optimal replication in their hosts. Our group and others have previously shown that p53 activity is finely modulated by different multilevel mechanisms during IAV infection. Here, we characterized IAV nonstructural protein NS1 and the cellular factor CPSF4 as major partners involved in the IAV-induced modulation of the\n                    <jats:italic>TP53<\/jats:italic>\n                    alternative splicing that was associated with a strong modulation of p53 activity and notably the p53-mediated antiviral response.\n                  <\/jats:p>","DOI":"10.1128\/jvi.02168-18","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T09:23:00Z","timestamp":1547630580000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["The Nonstructural NS1 Protein of Influenza Viruses Modulates\n                    <i>TP53<\/i>\n                    Splicing through Host Factor CPSF4"],"prefix":"10.1128","volume":"93","author":[{"given":"Julia","family":"Dubois","sequence":"first","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France"},{"name":"Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Qu\u00e9bec and Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Traversier","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Julien","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Padey","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lina","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France"},{"name":"Laboratoire de Virologie, Centre National de R\u00e9f\u00e9rence des Virus Influenza, Institut des Agents Infectieux, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Bourdon","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Marcel","sequence":"additional","affiliation":[{"name":"INSERM U1052, CNRS UMR5286, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon, Lyon, France"},{"name":"Centre L\u00e9on B\u00e9rard, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Boivin","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Qu\u00e9bec and Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rosa-Calatrava","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-7684","authenticated-orcid":false,"given":"Olivier","family":"Terrier","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30129-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-2659.2011.00231.x"},{"key":"e_1_3_3_4_2","first-page":"1151","volume-title":"Fields virology","author":"Palese PSM","year":"2013","unstructured":"Palese PSM. 2013. 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