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Because of overlapping geographic occurrences and similarities in mode of entry into cells, we seek a practical drug or drug cocktail that could be used to treat infections by both viruses. Toward this goal, we directly compared eight drugs, approved or in clinical testing, for the ability to block entry mediated by the glycoproteins of both viruses. We identified five drugs with approximately equal potencies against both. Among these, we investigated the modes of action of arbidol, a drug licensed abroad to treat influenza infections. We found, as shown for influenza virus, that arbidol blocks fusion mediated by the Lassa virus glycoprotein. Our findings encourage the development of a combination of approved drugs to treat both Lassa and Ebola virus diseases.<\/jats:p>","DOI":"10.1128\/jvi.02185-18","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T11:53:31Z","timestamp":1548676411000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":103,"title":["Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses"],"prefix":"10.1128","volume":"93","author":[{"given":"C. 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