{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:29:12Z","timestamp":1791221352915,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"13","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>T cell costimulation is important for T cell activation. The CD27\/CD70 pathway contributes to effector and memory T cell development and is involved in T cell and B cell activation. CD27\/CD70 is known for having opposing roles during different models of antigenic challenges. During primary T cell responses to influenza virus infection or during tumor challenges, CD27\/CD70 costimulation has a positive role on T cell responses. However, during some chronic infections, constitutive triggering of this signaling pathway has a negative role on T cell responses. It is currently unclear what specific characteristic of an antigen determines the outcome of CD27\/CD70 costimulation. We investigated the effect of a transient CD70 blockade during an acute or a chronic lymphocytic choriomeningitis virus (LCMV) infection in mice. Blockade of this pathway during acute LCMV infection (Armstrong strain) resulted in delayed T cell responses and decreased CD127 (interleukin-7 receptor \u03b1 [IL-7R\u03b1] chain) conversion. Upregulation of CD127 is an important event in T cell differentiation that heralds the passage of an effector T cell to a long-lived memory T cell. In contrast to the reduced CD8 T cell responses after CD70 blockade during acute infection, CD70 blockade during chronic LCMV infection resulted in increased CD8 T cell responses. Our data show the dual roles of this costimulatory pathway in acute versus persistent antigen challenge. Our findings suggest that antigen persistence may determine the effect of CD27\/CD70 signaling on CD8 T cell responses. Tailored triggering or blockade of this costimulatory pathway may be important in vaccination regimens against acute or chronic pathogens.<\/jats:p>","DOI":"10.1128\/jvi.02205-10","type":"journal-article","created":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T00:14:32Z","timestamp":1303431272000},"page":"6168-6174","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":57,"title":["Opposing Effects of CD70 Costimulation during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection of Mice"],"prefix":"10.1128","volume":"85","author":[{"given":"Pablo","family":"Penaloza-MacMaster","sequence":"first","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ata Ur","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita S.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yagita","sequence":"additional","affiliation":[{"name":"Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Blazar","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.5.1719"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.521"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031111"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00236-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1838"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(96)02693-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609706104"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80143-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700861"},{"key":"e_1_3_3_11_2","first-page":"163","article-title":"Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells","volume":"5","author":"Couderc B.","year":"1998","unstructured":"CoudercB. . 1998. Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells. Cancer Gene Ther. 5:163\u2013175.","journal-title":"Cancer Gene Ther."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2526"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.2912"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg038"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.2.489.489"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.4049\/jimmunol.155.11.5167","article-title":"B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors","volume":"155","author":"Guerder S.","year":"1995","unstructured":"GuerderS. CardingS. R. FlavellR. A.. 1995. B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors. J. Immunol. 155:5167\u20135174.","journal-title":"J. Immunol."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705007104"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/80877"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030916"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.4049\/jimmunol.151.5.2426","article-title":"Regulation of CD27 expression on subsets of mature T-lymphocytes","volume":"151","author":"Hintzen R. Q.","year":"1993","unstructured":"HintzenR. Q. . 1993. Regulation of CD27 expression on subsets of mature T-lymphocytes. J. Immunol. 151:2426\u20132435.","journal-title":"J. Immunol."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00250-06"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1009"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-148007"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.24.11249"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060651"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-199805000-00009"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.4.517"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.271"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42056"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.4.1863-1869.1991"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(88)90566-1"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri727"},{"key":"e_1_3_3_33_2","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.4049\/jimmunol.162.9.5037","article-title":"Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal","volume":"162","author":"Takahashi C.","year":"1999","unstructured":"TakahashiC. MittlerR. S. VellaA. T.. 1999. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J. Immunol. 162:5037\u20135040.","journal-title":"J. Immunol."},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni869"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802809"},{"key":"e_1_3_3_36_2","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.4049\/jimmunol.139.5.1589","article-title":"Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen","volume":"139","author":"van Lier R. A.","year":"1987","unstructured":"van LierR. A. . 1987. Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. J. Immunol. 139:1589\u20131596.","journal-title":"J. Immunol."},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.11.5535-5545.2004"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.4911-4927.2003"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260806"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03255.x"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02205-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02205-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T12:21:48Z","timestamp":1686054108000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02205-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":39,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1128\/JVI.02205-10"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02205-10","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"2010-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}