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Inhibition of the GTPase Rab 5 or 7, which regulates transport to early or late endosomes, respectively, demonstrated that Rab 5 was essential for survival of both dengue and West Nile virus. These data broaden our understanding of the pathways required for productive dengue and West Nile virus infection and may facilitate new strategies for combating disease.<\/jats:p>","DOI":"10.1128\/jvi.02210-06","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:28:51Z","timestamp":1171502931000},"page":"4881-4885","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":217,"title":["Rab 5 Is Required for the Cellular Entry of Dengue and West Nile Viruses"],"prefix":"10.1128","volume":"81","author":[{"given":"Manoj N.","family":"Krishnan","sequence":"first","affiliation":[{"name":"Section of Rheumatology, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Sukumaran","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utpal","family":"Pal","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve","family":"Agaisse","sequence":"additional","affiliation":[{"name":"Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Murray","sequence":"additional","affiliation":[{"name":"University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases, Athens, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Hodge","sequence":"additional","affiliation":[{"name":"University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases, Athens, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Internal Medicine"},{"name":"Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5448.2331"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.56.012302.160654"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.19.10543-10555.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01257-06"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-9-1969"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-1-157"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.03.069"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2005.00336.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.1.139"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-11-2423"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-6-1247"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050561"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.007"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01717-06"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025768529677"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.19.10776-10782.2004"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-001-0348-0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(99)00042-4"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.35.22161"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200011)62:3<364::AID-JMV9>3.0.CO;2-S"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2003.00090.x"},{"key":"e_1_3_2_23_2","first-page":"1","volume":"285","year":"2005","unstructured":"Sieczkarski, S. 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