{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:00:18Z","timestamp":1792159218980,"version":"4.4.0"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI119187"],"award-info":[{"award-number":["AI119187"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM128624"],"award-info":[{"award-number":["GM128624"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    A 2014 EV-D68 outbreak in the United States has been linked to the development of acute flaccid myelitis in children. Unfortunately, no treatment options against EV-D68 are currently available, and the development of effective therapeutics is urgently needed. Here, we characterize and validate a new EV-D68 drug target, the 2A\n                    <jats:sup>pro<\/jats:sup>\n                    , and identify telaprevir\u2014an FDA-approved drug used to treat hepatitis C virus (HCV) infections\u2014as a potent antiviral with a novel mechanism of action toward 2A\n                    <jats:sup>pro<\/jats:sup>\n                    . 2A\n                    <jats:sup>pro<\/jats:sup>\n                    functions as a viral protease that cleaves a peptide sequence corresponding to the VP1-2A polyprotein junction. The binding of telaprevir potently inhibits its enzymatic activity, and using drug resistance selection, we show that the potent antiviral activity of telaprevir was due to 2A\n                    <jats:sup>pro<\/jats:sup>\n                    inhibition. This is the first inhibitor to selectively target the 2A\n                    <jats:sup>pro<\/jats:sup>\n                    from EV-D68 and can be used as a starting point for the development of therapeutics with selective activity against EV-D68.\n                  <\/jats:p>","DOI":"10.1128\/jvi.02221-18","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T06:48:47Z","timestamp":1548053327000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":70,"title":["Validating Enterovirus D68-2A\n                    <sup>pro<\/sup>\n                    as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2A\n                    <sup>pro<\/sup>\n                    Inhibitor"],"prefix":"10.1128","volume":"93","author":[{"given":"Rami","family":"Musharrafieh","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, USA"},{"name":"Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica 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