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Successful primary infection and persistent coexistence with host immune defenses are dependent on the ability of these viruses to counter the antiviral response. HSV-1 and HSV-2 and other primate viruses within the\n            <jats:italic>Simplexvirus<\/jats:italic>\n            genus encode US11, an immune antagonist that promotes virus production by preventing shutdown of protein translation. Here we investigated the impact of US11 deletion on HSV-1 growth\n            <jats:italic>in vitro<\/jats:italic>\n            and pathogenesis\n            <jats:italic>in vivo<\/jats:italic>\n            . This work supports a role for US11 in pathogenesis and emergence from latency, elucidating immunomodulation by this medically important cohort of viruses.\n          <\/jats:p>","DOI":"10.1128\/jvi.02246-18","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T11:38:35Z","timestamp":1549971515000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["The US11 Gene of Herpes Simplex Virus 1 Promotes Neuroinvasion and Periocular Replication following Corneal Infection"],"prefix":"10.1128","volume":"93","author":[{"given":"Audra J.","family":"Charron","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and 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