{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:35:08Z","timestamp":1791329708712,"version":"4.3.1"},"reference-count":60,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2009,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The Epstein-Barr virus (EBV) latency III program imposed by EBNA2 and LMP1 is directly responsible for immortalization of B cells in vitro and is thought to mediate most immunodeficiency-related posttransplant lymphoproliferative diseases in vivo. To answer the question whether and how this proliferation program is related to c-Myc, we have established the transcriptome of both c-Myc and EBV latency III proliferation programs using a Lymphochip specialized microarray. In addition to EBV-positive latency I Burkitt lymphoma lines and lymphoblastoid cell lines (LCLs), we used an LCL expressing an estrogen-regulatable EBNA2 fusion protein (EREB2-5) and derivative B-cell lines expressing a constitutively active or tetracycline-regulatable c-\n            <jats:italic>myc<\/jats:italic>\n            gene. A total of 897 genes were found to be fourfold or more up- or downregulated in either one or both proliferation programs compared to the expression profile of resting EREB2-5 cells. A total of 661 (74%) of these were regulated similarly in both programs. Numerous repressed genes were known targets of STAT1, and most induced genes were known to be upregulated by c-Myc and to be involved in cell proliferation. In keeping with the gene expression patterns, inactivation of c-Myc by a chemical inhibitor or by conditional expression of dominant-negative c-Myc and Max mutants led to proliferation arrest of LCLs. Most genes differently regulated in both proliferation programs corresponded to genes induced by NF-\u03baB in LCLs, and many of them coded for immunoregulatory and\/or antiapoptotic molecules. Thus, c-Myc and NF-\u03baB are the two main transcription factors responsible for the phenotype, growth pattern, and biological properties of cells driven into proliferation by EBV.\n          <\/jats:p>","DOI":"10.1128\/jvi.02264-08","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T04:41:16Z","timestamp":1236314476000},"page":"5014-5027","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["c-Myc and Rel\/NF-\u03baB Are the Two Master Transcriptional Systems Activated in the Latency III Program of Epstein-Barr Virus-Immortalized B Cells"],"prefix":"10.1128","volume":"83","author":[{"given":"Nathalie","family":"Faumont","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 6101, Centre Hospitalier Universitaire Dupuytren, Universite\u0301 de Limoges, Laboratoire d'He\u0301matologie, 2 rue du Docteur Marcland, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ste\u0301phanie","family":"Durand-Panteix","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 6101, Centre Hospitalier Universitaire Dupuytren, Universite\u0301 de Limoges, Laboratoire d'He\u0301matologie, 2 rue du Docteur Marcland, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schlee","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, 81377 Munich, Germany"},{"name":"Institute of Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Gro\u0308mminger","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Schuhmacher","sequence":"additional","affiliation":[{"name":"GPC Biotech AG, 82152 Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ho\u0308lzel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Laux","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Mailhammer","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rosenwald","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis M.","family":"Staudt","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg W.","family":"Bornkamm","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Feuillard","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 6101, Centre Hospitalier Universitaire Dupuytren, Universite\u0301 de Limoges, Laboratoire d'He\u0301matologie, 2 rue du Docteur Marcland, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.10.009"},{"key":"e_1_3_2_4_2","first-page":"2475","volume":"104","year":"2004","unstructured":"Baran-Marszak, F., J. 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