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However, little is known about the interaction of these viruses with cells of the CNS. Differences among seasonal, pandemic, and zoonotic influenza viruses in replication efficacy in CNS cells,\n                    <jats:italic>in vitro<\/jats:italic>\n                    , suggest that the presence of an alternative HA cleavage mechanism and ability to attach are important viral factors. Identifying these viral factors and detailed knowledge of the interaction between influenza virus and CNS cells are important to prevent and treat this potentially lethal CNS disease.\n                  <\/jats:p>","DOI":"10.1128\/jvi.02273-18","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T06:32:51Z","timestamp":1552372371000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System"],"prefix":"10.1128","volume":"93","author":[{"given":"Jurre Y.","family":"Siegers","sequence":"first","affiliation":[{"name":"Department of Viroscience, Erasmus MC Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco W. 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