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Upon infection, MDV induces DNA damage, which may activate the DDR pathway. The DDR pathway has a dual impact on viruses because it manipulates repair and recombination factors to facilitate viral replication and also initiates antiviral action by regulating other signaling pathways. Many DNA viruses evolve to manipulate the DDR pathway to promote virus replication. In this study, we identified a mechanism used by MDV to inhibit ATR-Chk1 pathways. ATR is a cellular kinase that responds to broken single-stranded DNA, which has been less studied in MDV infection. Our results suggest that MDV infection activates STAT3 to disable the ATR-Chk1 pathway, which is conducive to viral replication. This finding provides new insight into the role of STAT3 in interrupting the ATR-Chk1 pathway during MDV replication.<\/jats:p>","DOI":"10.1128\/jvi.02290-18","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T14:02:31Z","timestamp":1550671351000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Marek's Disease Virus Disables the ATR-Chk1 Pathway by Activating STAT3"],"prefix":"10.1128","volume":"93","author":[{"given":"Xue","family":"Lian","sequence":"first","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"},{"name":"Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"},{"name":"Jiangsu Vocational College of Agriculture and Forestry, Jurong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyi","family":"Bao","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"},{"name":"Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqi","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"},{"name":"Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunhai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory for Control and Monitoring of Poultry Diseases, Anhui Science and Technology University, Fengyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Veterinary Research Institute, Chinese Academic of Agricultural Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-162X","authenticated-orcid":false,"given":"Yong-Sam","family":"Jung","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"},{"name":"Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjuan","family":"Qian","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"},{"name":"Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"25","article-title":"Pathogenesis of Marek's disease virus infection","volume":"255","author":"Calnek BW","year":"2001","unstructured":"Calnek BW. 2001. 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