{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:11:32Z","timestamp":1789193492882,"version":"build-2803163510"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"15","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"crossref","award":["2013-20020120100033"],"award-info":[{"award-number":["2013-20020120100033"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005961","name":"National University of Cuyo","doi-asserted-by":"crossref","award":["2013-2015 M006"],"award-info":[{"award-number":["2013-2015 M006"]}],"id":[{"id":"10.13039\/501100005961","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005961","name":"National University of Cuyo","doi-asserted-by":"crossref","award":["2016-2018 M029"],"award-info":[{"award-number":["2016-2018 M029"]}],"id":[{"id":"10.13039\/501100005961","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003033","name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n Productiva","doi-asserted-by":"publisher","award":["PICT 2016-0528"],"award-info":[{"award-number":["PICT 2016-0528"]}],"id":[{"id":"10.13039\/501100003033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>\n            Mammalian arenaviruses are zoonotic viruses that cause asymptomatic and persistent infections in their rodent hosts but may produce severe and lethal hemorrhagic fevers in humans. Currently, there are neither effective therapeutic options nor effective vaccines for viral hemorrhagic fevers caused by human-pathogenic arenaviruses, except the vaccine Candid no. 1 against Argentine hemorrhagic fever (AHF), licensed for human use in areas of endemicity in Argentina. Since arenaviruses remain a severe threat to global public health, more in-depth knowledge of their replication mechanisms would improve our ability to fight these viruses. Autophagy is a lysosomal degradative pathway involved in maintaining cellular homeostasis, representing powerful anti-infective machinery. We show, for the first time for a member of the family\n            <jats:italic>Arenaviridae<\/jats:italic>\n            , a proviral role of autophagy in JUNV infection, providing new knowledge in the field of host-virus interaction. Therefore, modulation of virus-induced autophagy could be used as a strategy to block arenavirus infections.\n          <\/jats:p>","DOI":"10.1128\/jvi.02307-18","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T13:42:10Z","timestamp":1558446130000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Jun\u00edn Virus Promotes Autophagy To Facilitate the Virus Life Cycle"],"prefix":"10.1128","volume":"93","author":[{"given":"Julieta S.","family":"Rold\u00e1n","sequence":"first","affiliation":[{"name":"Laboratorio de Virolog\u00eda, Departamento de Qu\u00edmica Biol\u00f3gica, IQUIBICEN, CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9lida A.","family":"Candurra","sequence":"additional","affiliation":[{"name":"Laboratorio de Virolog\u00eda, Departamento de Qu\u00edmica Biol\u00f3gica, IQUIBICEN, CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda I.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza (IHEM), CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3647-3593","authenticated-orcid":false,"given":"Laura R.","family":"Delgui","sequence":"additional","affiliation":[{"name":"Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza (IHEM), CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Mendoza, Argentina"},{"name":"Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1792","volume-title":"Fields Virology","author":"Buchmeier MJ","year":"2007","unstructured":"Buchmeier MJ. 2007. Arenaviridae: the virus and their replication, p 1792\u20131827. In Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (ed), Fields Virology, 5th ed, vol 2. Lippincott Williams & Wilkins, Philadelphia, PA.","edition":"5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2008.06.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000455"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1970.19.670"},{"key":"e_1_3_2_6_2","first-page":"2300","article-title":"Concerning the epidemic outbreak in Junin","volume":"30","author":"Parodi AS","year":"1958","unstructured":"Parodi AS, Greenway DJ, Rugiero HR, Frigerio M, De La Barrera JM, Mettler N, Garzon F, Boxaca M, Guerrero L, Nota N. 1958. Concerning the epidemic outbreak in Junin. Dia Med 30:2300\u20132301.","journal-title":"Dia Med"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/514211"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.46.2.638-641.1983"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.19.10783-10792.2004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2079"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.10.5140-5146.2002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05539"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.10.106"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01321064"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0910-814"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.02.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.09.021"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.042"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.5.14732"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.02.016"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00755-07"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5184"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.01.005"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.2176"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells2010083"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.21.5720"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.7.3963"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.0240a.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.4600"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.028"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-9-39"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.4.657"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00846-12"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.09.005"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2014.07.016"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.03.002"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1846"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7068"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.118125"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.12.17802"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.51"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.53"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009996"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002664"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01397-07"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.1225"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1057"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1159\/000346388"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401833"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607007200"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2239"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01090-1"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00020"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7383-5"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00050-14"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.31"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05304-11"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01635-12"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890120407"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001137"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2009.07.004"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-70-5-1125"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_2_64_2","volume-title":"InfoStat statistical software","author":"Di Rienzo JA","year":"2014","unstructured":"Di Rienzo JA, Casanoves F, Balzarini M, Gonzalez L, Tablada M, Robledo CW. 2014. InfoStat statistical software. National University of C\u00f3rdoba, C\u00f3rdoba, Argentina."}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02307-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02307-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T14:47:13Z","timestamp":1646491633000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02307-18"}},"subtitle":[],"editor":[{"given":"Susana","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":63,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1128\/JVI.02307-18"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02307-18","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"2018-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02307-18"}}