{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:13:27Z","timestamp":1790842407081,"version":"4.1.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"13","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n            T cells are central to an effective defense against persistent viral infections that can be related to human cytomegalovirus (HCMV) or human herpesvirus 6 (HHV-6). However, knowledge of HHV-6-specific T-cell responses is limited. In order to deepen our knowledge of T-cell responses to HHV-6, we characterized HHV-6A- and HHV-6B-specific CD4\n            <jats:sup>+<\/jats:sup>\n            and CD8\n            <jats:sup>+<\/jats:sup>\n            T-cell responses directly\n            <jats:italic>ex vivo<\/jats:italic>\n            from healthy coinfected blood donors. Despite the strong similarity of HHV-6 and HCMV from a virologic point of view, we observed immunological differences, particularly in relation to the frequency and phenotype of effector\/memory and regulatory virus-specific T cells. This suggests that different immune factors are solicited in the control of HHV-6 infection than in that of HCMV infection. Our findings may encourage immunomonitoring of patients with viral replication episodes to follow the emergence of effector versus regulatory T cells.\n          <\/jats:p>","DOI":"10.1128\/jvi.02321-18","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T10:53:17Z","timestamp":1555411997000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Phenotypic and Functional Differences between Human Herpesvirus 6- and Human Cytomegalovirus-Specific T Cells"],"prefix":"10.1128","volume":"93","author":[{"given":"Sol\u00e8ne","family":"Fastenackels","sequence":"first","affiliation":[{"name":"INSERM 1135, Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Bayard","sequence":"additional","affiliation":[{"name":"INSERM 1135, Centre 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