{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:12:45Z","timestamp":1792177965310,"version":"4.4.0"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"24","license":[{"start":{"date-parts":[[2007,12,15]],"date-time":"2007-12-15T00:00:00Z","timestamp":1197676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Rabies virus glycoprotein (RVG) is known to be the only factor that mediates rabies infection. The neurotrophin receptor (p75\n            <jats:sup>NTR<\/jats:sup>\n            ), through its cysteine-rich domain 1, is a specific receptor for RVG and neutralizes virus infectivity, but its role in virus infection has remained obscure. We used adult mouse dorsal root ganglion (DRG) neurons as a model to study the role of p75\n            <jats:sup>NTR<\/jats:sup>\n            in RV infection of primary neurons. We show that RV infects around 20% of DRG neurons, of which more than 80% are p75\n            <jats:sup>NTR<\/jats:sup>\n            positive, have large diameters, and are capsaicin insensitive. Surprisingly, RV binding and infection are absent in about half of the p75\n            <jats:sup>NTR<\/jats:sup>\n            -expressing DRG neurons which have small diameters and are often capsaicin sensitive. This indicates that p75\n            <jats:sup>NTR<\/jats:sup>\n            is not sufficient to mediate RV interaction in sensory neurons. The rate and specificity of neural infection are unchanged in RV-infected p75\n            <jats:sup>NTRExonIV\u2212\/\u2212<\/jats:sup>\n            mice that lack all extracellular receptor domains and in wild-type mice infected with two independent RV mutants that lack p75\n            <jats:sup>NTR<\/jats:sup>\n            binding. Accordingly, the mortality rate is unchanged in the absence of RV-p75\n            <jats:sup>NTR<\/jats:sup>\n            interaction. We conclude that although p75\n            <jats:sup>NTR<\/jats:sup>\n            is a receptor for soluble RVG in transfected cells of heterologous expression systems, an RVG-p75\n            <jats:sup>NTR<\/jats:sup>\n            interaction is not necessary for RV infection of primary neurons. This means that other receptors are required to mediate RV infection in vivo and in vitro.\n          <\/jats:p>","DOI":"10.1128\/jvi.02368-06","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T00:39:28Z","timestamp":1192063168000},"page":"13622-13630","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":75,"title":["The Rabies Virus Glycoprotein Receptor p75\n            <sup>NTR<\/sup>\n            Is Not Essential for Rabies Virus Infection"],"prefix":"10.1128","volume":"81","author":[{"given":"Christine","family":"Tuffereau","sequence":"first","affiliation":[{"name":"Laboratoire de Virologie Mole\u0301culaire et Structurale, UMR 2472 CNRS-INRA, CNRS, 91198 Gif-sur-Yvette Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Langevin","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie Mole\u0301culaire et Structurale, UMR 2472 CNRS-INRA, CNRS, 91198 Gif-sur-Yvette Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lafay","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie Mole\u0301culaire et Structurale, UMR 2472 CNRS-INRA, CNRS, 91198 Gif-sur-Yvette Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Dechant","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Koltzenburg","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany"},{"name":"UCL Institute of Child Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.7.3268-3276.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.9.4594"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01349.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.7.3427-3434.2001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00440-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02408-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/13550280500187252"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5464.306"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20262"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1078"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480251106"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.8.3550-3554.1989"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1102-1131"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.08.018"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107454200"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-9-2147"},{"key":"e_1_3_2_19_2","first-page":"577","volume":"193","year":"1996","unstructured":"Garcia-Suarez, O., F. 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