{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:23:21Z","timestamp":1760984601975},"reference-count":63,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2013,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus that causes chickenpox during primary infection and establishes latency in sensory ganglia. Infection of rhesus macaques (RM) with the homologous simian varicella virus (SVV) recapitulates hallmarks of VZV infection. We have shown that an antisense transcript of SVV open reading frame 61 (ORF61), a viral transactivator, was detected most frequently in latently infected RM sensory ganglia. In this study, we compared disease progression, viral replication, immune response, and the establishment of latency following intrabronchial infection with a recombinant SVV lacking ORF61 (SVV\u0394ORF61) to those following infection with wild-type (WT) SVV. Varicella severity and viral latency within sensory ganglia were comparable in RMs infected with SVV\u0394ORF61 and WT SVV. In contrast, viral loads, B and T cell responses, and plasma inflammatory cytokine levels were decreased in RMs infected with SVV\u0394ORF61. To investigate the mechanisms underlying the reduced adaptive immune response, we compared acute SVV gene expression, frequency and proliferation of dendritic cell (DC) subsets, and the expression of innate antiviral genes in bronchoalveolar lavage (BAL) samples. The abundance of SVV transcripts in all kinetic classes was significantly decreased in RMs infected with SVV\u0394ORF61. In addition, we detected a higher frequency and proliferation of plasmacytoid dendritic cells in BAL fluid at 3 days postinfection in RMs infected with SVV\u0394ORF61, which was accompanied by a slight increase in type I interferon gene expression. Taken together, our data suggest that ORF61 plays an important role in orchestrating viral gene expression<jats:italic>in vivo<\/jats:italic>and interferes with the host antiviral interferon response.<\/jats:p>","DOI":"10.1128\/jvi.02369-12","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T03:32:58Z","timestamp":1354764778000},"page":"2151-2163","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Attenuation of the Adaptive Immune Response in Rhesus Macaques Infected with Simian Varicella Virus Lacking Open Reading Frame 61"],"prefix":"10.1128","volume":"87","author":[{"given":"Christine","family":"Meyer","sequence":"first","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Kerns","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Haberthur","sequence":"additional","affiliation":[{"name":"Molecular Microbiology and Immunology Department, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Dewane","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Walker","sequence":"additional","affiliation":[{"name":"Molecular Microbiology and Immunology Department, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Arkansas, Little Rock, Arkansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhem","family":"Messaoudi","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Portland, Oregon, USA"},{"name":"Molecular Microbiology and Immunology Department, Oregon Health &amp; Science University, Portland, Oregon, USA"},{"name":"Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1","article-title":"Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"57","author":"Harpaz R","year":"2008","unstructured":"HarpazR Ortega-SanchezIR SewardJF. 2008. Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep. 57:1\u201330.","journal-title":"MMWR Recomm. Rep."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.0150.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051016"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4065\/82.11.1341"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70312-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(00)70004-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.3.422"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.32.1.24-27.1981"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1982.00340150091017"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/320169"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000657"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-011-0057-y"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00407-07"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.12.4637"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-9-1759"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-006-0866-0"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.0912"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90706-U"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.5.2763-2772.1992"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00077-5"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.21.10006-10017.2000"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002367"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90022-H"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.2144\/02332rr04"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/4806"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-3-31"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-010-0889-4"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01997-06"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05047-11"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.1.29"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/smim.2001.0293"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/088282402760312377"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4049\/jimmunol.146.1.257","article-title":"Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype","volume":"146","author":"Arvin AM","year":"1991","unstructured":"ArvinAM SharpM SmithS KoropchakCM DiazPS KinchingtonP RuyechanW HayJ. 1991. Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype. J. Immunol. 146:257\u2013264.","journal-title":"J. Immunol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.4049\/jimmunol.159.6.2802","article-title":"Recognition of the latency-associated immediate early protein IE63 of varicella-zoster virus by human memory T lymphocytes","volume":"159","author":"Sadzot-Delvaux C","year":"1997","unstructured":"Sadzot-DelvauxC KinchingtonPR DebrusS RentierB ArvinAM. 1997. Recognition of the latency-associated immediate early protein IE63 of varicella-zoster virus by human memory T lymphocytes. J. Immunol. 159:2802\u20132806.","journal-title":"J. Immunol."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05098-11"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06400-11"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1639"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-3-521"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9198"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.12.7303-7308.1992"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.7.4290-4295.1993"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00118-09"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00685-08"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20373"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00021-09"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00335-10"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002157"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/11360"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5421.1835"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.5.2180-2191.2002"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1280"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.3.843"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.4.1675-1684.2004"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.16.8411-8420.2004"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.2.750-758.2001"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.4.2052-2056.2000"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211302109"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.0941"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00325-07"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10326"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.12.7501-7512.1993"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.13.6143-6153.2001"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.7.3240-3249.2001"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02369-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02369-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T22:52:42Z","timestamp":1714690362000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02369-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,15]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,2,15]]}},"alternative-id":["10.1128\/JVI.02369-12"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02369-12","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,15]]},"assertion":[{"value":"2012-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}