{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:23:03Z","timestamp":1791397383203,"version":"4.3.3"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"14","license":[{"start":{"date-parts":[[2007,7,15]],"date-time":"2007-07-15T00:00:00Z","timestamp":1184457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2007,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The Epstein-Barr virus (EBV)-encoded leader protein, EBNA-LP, strongly activates the EBNA2-mediated transcriptional activation of cellular and viral genes and is therefore important for EBV-induced B-cell transformation. However, a truncated form of EBNA-LP is produced in cells infected with variant EBV strains lacking EBNA2 due to a genetic deletion. The function of this truncated form is unknown. We show here that some Burkitt's lymphoma cells harboring defective EBV strains are specifically resistant to the caspase-dependent apoptosis induced by verotoxin 1 (VT-1) or staurosporine. These cells produced low-molecular-weight Y1Y2-truncated isoforms of EBNA-LP, which were partly localized in the cytoplasm. The transfection of sensitive cells with constructs encoding truncated EBNA-LP isoforms, but not full-length EBNA-LP, induced resistance to caspase-mediated apoptosis. Furthermore, VT-1 induced protein phosphatase 2A (PP2A) activation in sensitive cells but not in resistant cells, in which the truncated EBNA-LP interacted with this protein. Thus, the resistance to apoptosis observed in cells harboring defective EBV strains most probably results from the inactivation of PP2A via interactions with low-molecular-weight Y1Y2-truncated EBNA-LP isoforms.<\/jats:p>","DOI":"10.1128\/jvi.02435-06","type":"journal-article","created":{"date-parts":[[2007,5,10]],"date-time":"2007-05-10T00:39:06Z","timestamp":1178757546000},"page":"7598-7607","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Truncated Form of the Epstein-Barr Virus Protein EBNA-LP Protects against Caspase-Dependent Apoptosis by Inhibiting Protein Phosphatase 2A"],"prefix":"10.1128","volume":"81","author":[{"given":"Julie","family":"Garibal","sequence":"first","affiliation":[{"name":"UMR 8126 CNRS, University Paris-Sud, Institut Gustave Roussy, 94805 Villejuif cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E\u0301milie","family":"Hollville","sequence":"additional","affiliation":[{"name":"UMR 8126 CNRS, University Paris-Sud, Institut Gustave Roussy, 94805 Villejuif cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew I.","family":"Bell","sequence":"additional","affiliation":[{"name":"Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma L.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Renouf","sequence":"additional","affiliation":[{"name":"UMR 8126 CNRS, University Paris-Sud, Institut Gustave Roussy, 94805 Villejuif cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan B.","family":"Rickinson","sequence":"additional","affiliation":[{"name":"Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe\u0308lle","family":"Wiels","sequence":"additional","affiliation":[{"name":"UMR 8126 CNRS, University Paris-Sud, Institut Gustave Roussy, 94805 Villejuif cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90893-G"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409718200"},{"key":"e_1_3_2_4_2","first-page":"541","volume":"18","year":"2003","unstructured":"Chen, W., and W. 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