{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:33:38Z","timestamp":1791279218220,"version":"4.1.0"},"reference-count":66,"publisher":"American Society for Microbiology","issue":"24","license":[{"start":{"date-parts":[[2013,12,15]],"date-time":"2013-12-15T00:00:00Z","timestamp":1387065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Measles virus (MV) infection causes an acute childhood disease that can include infection of the central nervous system and can rarely progress to severe neurological disease for which there is no specific treatment. We generated potent antiviral peptide inhibitors of MV entry and spreading and MV-induced cell fusion. Dimers of MV-specific peptides derived from the C-terminal heptad repeat region of the MV fusion protein, conjugated to cholesterol, efficiently protect SLAM transgenic mice from fatal MV infection. Fusion inhibitors hold promise for the prophylaxis of MV infection in unvaccinated and immunocompromised people, as well as potential for the treatment of grave neurological complications of measles.<\/jats:p>","DOI":"10.1128\/jvi.02436-13","type":"journal-article","created":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T15:49:00Z","timestamp":1381420140000},"page":"13785-13794","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":74,"title":["Fatal Measles Virus Infection Prevented by Brain-Penetrant Fusion Inhibitors"],"prefix":"10.1128","volume":"87","author":[{"given":"Jeremy C.","family":"Welsch","sequence":"first","affiliation":[{"name":"International Center for Research in Infectious Diseases\u2014CIRI, INSERM U1111, CNRS UMR5308, ENS\u2014Lyon, University of Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Talekar","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA"},{"name":"Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Pessi","sequence":"additional","affiliation":[{"name":"JV Bio and CEINGE, Naples, Italy"},{"name":"PeptiPharma, Pomezia, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Moscona","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA"},{"name":"Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Horvat","sequence":"additional","affiliation":[{"name":"International Center for Research in Infectious Diseases\u2014CIRI, INSERM U1111, CNRS UMR5308, ENS\u2014Lyon, University of Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Porotto","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60522-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62352-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis923"},{"key":"e_1_3_3_5_2","first-page":"811","article-title":"Measles control\u2014can measles virus inhibitors make a difference?","volume":"10","author":"Plemper RK","year":"2009","unstructured":"PlemperRKSnyderJP. 2009. Measles control\u2014can measles virus inhibitors make a difference? Curr. Opin. Investig. Drugs. 10:811\u2013820.","journal-title":"Curr. Opin. Investig. Drugs."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.0161"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2012.02.003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199604000-00010"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.01.093"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.04.009"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.09.007"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.03.050"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213802109"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2250"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234914"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1456"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00413-13"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10639"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002240"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.11.5720-5728.2002"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1134\/S0026893307010219"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211138109"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.4.1908-1918.2000"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.02.033"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.5.2186"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0459"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80458-X"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.21.9770"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsb1295-1075"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00416-09"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001168"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901007106"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036833"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.3.1505-1509.2002"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.2222\/jsv.52.169"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00164-09"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02617-06"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.6.1171"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(91)90128-M"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024135"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(88)90011-1"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00209-06"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032157"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.11.6900-6908.2005"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2005.03.020"},{"key":"e_1_3_3_46_2","first-page":"111","article-title":"Current animal models: transgenic animal models for the study of measles pathogenesis","volume":"330","author":"Sellin CI","year":"2009","unstructured":"SellinCIHorvatB. 2009. Current animal models: transgenic animal models for the study of measles pathogenesis. Curr. Top. Microbiol. Immunol. 330:111\u2013127.","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152611795768097"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.777"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00452-11"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004948"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-22"},{"key":"e_1_3_3_52_2","first-page":"3","article-title":"Making it to the synapse: measles virus spread in and among neurons","volume":"330","author":"Young VA","year":"2009","unstructured":"YoungVARallGF. 2009. Making it to the synapse: measles virus spread in and among neurons. Curr. Top. Microbiol. Immunol. 330:3\u201330.","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm201699w"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001241"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis386"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1017\/S095026881100238X"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.23265"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir135"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199708)52:4<362::AID-JMV3>3.0.CO;2-#"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(97)00139-1"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-010-9200-4"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-010-0153-2"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2012.00330.x"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-1-107"},{"key":"e_1_3_3_65_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/135965350801300312","article-title":"Enfuvirtide cerebrospinal fluid (CSF) pharmacokinetics and potential use in defining CSF HIV-1 origin","volume":"13","author":"Price RW","year":"2008","unstructured":"PriceRWParhamRKrollJLWringSABakerBSailstadJHohRLieglerTSpudichSKuritzkesDRDeeksSG. 2008. Enfuvirtide cerebrospinal fluid (CSF) pharmacokinetics and potential use in defining CSF HIV-1 origin. Antivir. Ther. 13:369\u2013374.","journal-title":"Antivir. Ther."},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc300076f"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02632-12"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02436-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02436-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T15:32:33Z","timestamp":1716046353000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02436-13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,15]]},"references-count":66,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2013,12,15]]}},"alternative-id":["10.1128\/JVI.02436-13"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02436-13","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,15]]},"assertion":[{"value":"2013-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}