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Here we show that CVA24v fails to bind to and infect CHO cells defective in sialic acid expression. Binding of CVA24v to and infection of corneal epithelial cells are efficiently inhibited by treating cells with a sialic acid-cleaving enzyme or sialic acid-binding lectins and by treatment of the virus with soluble, multivalent sialic acid. Protease treatment of cells efficiently inhibited virus binding, suggesting that the receptor is a sialylated glycoprotein. Like enterovirus type 70 and influenza A virus, CVA24v can cause pandemics. Remarkably, all three viruses use the same receptor. Since several unrelated viruses with tropism for the eye use this receptor, sialic acid-based antiviral drugs that prevent virus entry may be useful for topical treatment of such infections.<\/jats:p>","DOI":"10.1128\/jvi.02470-07","type":"journal-article","created":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T01:46:15Z","timestamp":1199929575000},"page":"3061-3068","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":67,"title":["Sialic Acid Is a Cellular Receptor for Coxsackievirus A24 Variant, an Emerging Virus with Pandemic Potential"],"prefix":"10.1128","volume":"82","author":[{"given":"Emma C.","family":"Nilsson","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Division of Virology, Umea\u030a University, Umea\u030a SE-901 85, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Division of Virology, Umea\u030a University, Umea\u030a SE-901 85, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne M. 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