{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:10:31Z","timestamp":1769040631617,"version":"3.49.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2013,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Our previous study had reported on the interaction of rotavirus NSP1 with cellular phosphoinositide 3-kinase (PI3K) during activation of the PI3K pathway (P. Bagchi et al., J. Virol. 84:6834\u20136845, 2010). In this study, we have analyzed the molecular mechanism behind this interaction. Results showed that this interaction is direct and that both \u03b1 and \u03b2 isomers of the PI3K regulatory subunit p85 and full-length NSP1 are important for this interaction, which results in efficient activation of the PI3K\/Akt pathway during rotavirus infection.<\/jats:p>","DOI":"10.1128\/jvi.02479-12","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T03:32:58Z","timestamp":1354764778000},"page":"2358-2362","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Molecular Mechanism behind Rotavirus NSP1-Mediated PI3 Kinase Activation: Interaction between NSP1 and the p85 Subunit of PI3 Kinase"],"prefix":"10.1128","volume":"87","author":[{"given":"Parikshit","family":"Bagchi","sequence":"first","affiliation":[{"name":"Division of Virology, National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satabdi","family":"Nandi","sequence":"additional","affiliation":[{"name":"Division of Virology, National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukti Kant","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Calcutta, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamta","family":"Chawla-Sarkar","sequence":"additional","affiliation":[{"name":"Division of Virology, National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.46.30199"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02020-07"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01309.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02082-06"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00964.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.13.8388-8399.2005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00245-09"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82419-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708862200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.1.220-231.2002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc798"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00225-10"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.03.003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1492"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02479-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02479-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:35:26Z","timestamp":1646494526000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02479-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,15]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,2,15]]}},"alternative-id":["10.1128\/JVI.02479-12"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02479-12","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,15]]},"assertion":[{"value":"2012-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}