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Pigs are an important intermediate host for influenza; thus, we assessed the replication ability of three human H7N9 viruses (A\/Anhui\/1\/2013, A\/Shanghai\/1\/2013, A\/Shanghai\/2\/2013) in swine tissue explants. All viruses tested replicated efficiently in explants from tracheas and bronchi, with limited replication in alveolar cells. Swine respiratory tissue explants can serve as an efficient model for screening replication potential of newly emerging H7N9 viruses.<\/jats:p>","DOI":"10.1128\/jvi.02499-13","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T02:23:49Z","timestamp":1378952629000},"page":"12496-12498","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Human H7N9 Influenza A Viruses Replicate in Swine Respiratory Tissue Explants"],"prefix":"10.1128","volume":"87","author":[{"given":"J. C.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Baranovich","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zaraket","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Guan","sequence":"additional","affiliation":[{"name":"Joint Influenza Research Centre [Shantou University Medical College (SUMC)\/University of Hong Kong (HKU)], Shantou University, Shantou, People's Republic of China"},{"name":"State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen, People's Republic of China"},{"name":"State Key Laboratory of Emerging Infectious Diseases\/Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong SAR, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Shu","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Webby","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"Webster","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60943-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60938-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60903-4"},{"key":"e_1_3_2_5_2","volume-title":"Human infection with avian influenza A(H7N9) virus---update","author":"World Health Organization","year":"2013","unstructured":"World Health Organization. 20 July 2013, posting date. 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