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Given that this neurotropism is attributed to the glycoprotein VSV-G, VSV was pseudotyped with the nonneurotropic envelope glycoprotein of the lymphocytic choriomeningitis virus (LCMV-GP\u2192VSV-GP). Compared to VSV, VSV-GP showed enhanced infectivity for brain cancer cells\n            <jats:named-content content-type=\"genus-species\">in vitro<\/jats:named-content>\n            while sparing primary human and rat neurons\n            <jats:named-content content-type=\"genus-species\">in vitro<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">in vivo<\/jats:named-content>\n            , respectively. In conclusion, VSV-GP has a much wider therapeutic window than VSV and is thus more suitable for clinical applications, especially in the brain.\n          <\/jats:p>","DOI":"10.1128\/jvi.02511-10","type":"journal-article","created":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T01:59:24Z","timestamp":1301536764000},"page":"5679-5684","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":90,"title":["Pseudotyping Vesicular Stomatitis Virus with Lymphocytic Choriomeningitis Virus Glycoproteins Enhances Infectivity for Glioma Cells and Minimizes Neurotropism"],"prefix":"10.1128","volume":"85","author":[{"given":"Alexander","family":"Muik","sequence":"first","affiliation":[{"name":"Georg-Speyer-Haus, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Kneiske","sequence":"additional","affiliation":[{"name":"Georg-Speyer-Haus, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Werbizki","sequence":"additional","affiliation":[{"name":"Georg-Speyer-Haus, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Wilflingseder","sequence":"additional","affiliation":[{"name":"Division of Virology, Innsbruck Medical University, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsanan","family":"Giroglou","sequence":"additional","affiliation":[{"name":"Georg-Speyer-Haus, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Ebert","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kraft","sequence":"additional","affiliation":[{"name":"Institute of Neurology (Edinger Institute), University of Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Georg-Speyer-Haus, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Institute of Virology and Immunoprophylaxis, Mittelh\u00e4usern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Momma","sequence":"additional","affiliation":[{"name":"Institute of Neurology (Edinger Institute), University of Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"von Laer","sequence":"additional","affiliation":[{"name":"Division of Virology, Innsbruck Medical University, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209037"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.275"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2004.17.516"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.2.1061-1064.2001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.3.1488-1495.2002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.942798"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.13.6618-6635.2002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.8.6937-6945.1999"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.10.016"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01911-06"},{"key":"e_1_3_3_12_2","first-page":"1831","article-title":"Lymphocytic choriomeningitis virus: pathogenesis of acute central nervous system disease","volume":"30","author":"Cole G. 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