{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:48:45Z","timestamp":1791895725955,"version":"4.3.4"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2011,5,15]],"date-time":"2011-05-15T00:00:00Z","timestamp":1305417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in \u201cclassic\u201d orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model.<\/jats:p>","DOI":"10.1128\/jvi.02525-10","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T04:16:41Z","timestamp":1299730601000},"page":"4898-4909","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["A Novel Respiratory Model of Infection with Monkeypox Virus in Cynomolgus Macaques"],"prefix":"10.1128","volume":"85","author":[{"given":"Arthur J.","family":"Goff","sequence":"first","affiliation":[{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Chapman","sequence":"additional","affiliation":[{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Foster","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Department Center and School, Fort Sam Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Wlazlowski","sequence":"additional","affiliation":[{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Shamblin","sequence":"additional","affiliation":[{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Lin","sequence":"additional","affiliation":[{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Kreiselmeier","sequence":"additional","affiliation":[{"name":"Tripler Army Medical Center, Honolulu, Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Mucker","sequence":"additional","affiliation":[{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Paragas","sequence":"additional","affiliation":[{"name":"Integrated Research Facility NIAID\/NIH, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lawler","sequence":"additional","affiliation":[{"name":"Integrated Research Facility NIAID\/NIH, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hensley","sequence":"additional","affiliation":[{"name":"United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"303","article-title":"The morbid anatomy of smallpox","volume":"4","author":"Bras G","year":"1952","unstructured":"BrasG. 1952. 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Res."},{"key":"e_1_3_2_5_2","first-page":"37988","article-title":"New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible, final rule","volume":"67","author":"Federal Register","year":"2002","unstructured":"Federal Register. 2002. New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible, final rule. Fed. Regist. 67:37988\u201337998.","journal-title":"Fed. Regist."},{"key":"e_1_3_2_6_2","unstructured":"FennerF.\nR.W.\nWittekR.\nDumbellK. R.. 1989. The Orthopoxviruses. 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Armed Forces Institute of Pathology Washington DC."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1306.061540"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005769107"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780373"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02525-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02525-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T16:10:03Z","timestamp":1646496603000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02525-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,15]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,5,15]]}},"alternative-id":["10.1128\/JVI.02525-10"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02525-10","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,15]]},"assertion":[{"value":"2010-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}