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We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.<\/jats:p>","DOI":"10.1128\/jvi.02627-06","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T05:44:34Z","timestamp":1172727874000},"page":"6128-6133","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":69,"title":["Human Serum Amyloid A Protein Inhibits Hepatitis C Virus Entry into Cells"],"prefix":"10.1128","volume":"81","author":[{"given":"Zhaohui","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cai","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Molecular and Cellular Biochemistry and Graduate Center for Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Soo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deneys R.","family":"van der Westhuyzen","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Molecular and Cellular Biochemistry and Graduate Center for Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12766"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405009200"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.9.5774-5785.2005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305289200"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.13001-13014.2002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009266"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411555200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.13963-13973.2005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81646-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-005-8065-4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500490200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409666102"},{"key":"e_1_3_2_14_2","first-page":"374","volume":"81","year":"2006","unstructured":"Kapadia, S. 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