{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:56:44Z","timestamp":1791136604652,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2014,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Hematopoietic stem cells (HSCs) give rise to progenitors with potential to produce multiple cell types, including dendritic cells (DCs). DCs are the principal antigen-presenting cells and represent the crucial link between innate and adaptive immune responses. Bluetongue virus (BTV), an economically important\n            <jats:named-content content-type=\"genus-species\">Orbivirus<\/jats:named-content>\n            of the\n            <jats:named-content content-type=\"genus-species\">Reoviridae<\/jats:named-content>\n            family, causes a hemorrhagic disease mainly in sheep and occasionally in other species of ruminants. BTV is transmitted between its mammalian hosts by certain species of biting midges (\n            <jats:named-content content-type=\"genus-species\">Culicoides<\/jats:named-content>\n            spp.) and is a potent alpha interferon (IFN-\u03b1) inducer. In the present report, we show that BTV infects cells of hematopoietic origin but not HSCs in immunocompetent sheep. However, BTV infects HSCs in the absence of type I IFN (IFN-I) signaling\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            . Infection of HSCs\n            <jats:italic>in vitro<\/jats:italic>\n            results in cellular death by apoptosis. Furthermore, BTV infects bone marrow-derived DCs (BM-DCs), interfering with their development to mature DCs in the absence of type I IFN signaling. Costimulatory molecules CD80 and CD86 and costimulatory molecules CD40 and major histocompatibility complex class II (MHC-II) are affected by BTV infection, suggesting that BTV interferes with DC antigen-presenting capacity.\n            <jats:italic>In vivo<\/jats:italic>\n            , different DC populations are also affected during the course of infection, probably as a result of a direct effect of BTV replication in DCs and the production of infectious virus. These new findings suggest that BTV infection of HSCs and DCs can impair the immune response, leading to persistence or animal death, and that this relies on IFN-I.\n          <\/jats:p>","DOI":"10.1128\/jvi.02697-13","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T02:21:07Z","timestamp":1383186067000},"page":"859-867","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Type I Interferon Limits the Capacity of Bluetongue Virus To Infect Hematopoietic Precursors and Dendritic Cells\n            <i>In Vitro<\/i>\n            and\n            <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"88","author":[{"given":"Teresa","family":"Rodr\u00edguez-Calvo","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigaci\u00f3n Agraria y Alimentaria, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Manuel","family":"Rojas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigaci\u00f3n Agraria y Alimentaria, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigaci\u00f3n Agraria y Alimentaria, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Sevilla","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigaci\u00f3n Agraria y Alimentaria, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2008023"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012369368-6.50018-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(05)64004-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002477"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres\/2010007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-9571(94)90043-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(94)90123-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00626-09"},{"key":"e_1_3_2_10_2","first-page":"629","article-title":"Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types","volume":"45","author":"Jeggo MH","year":"1982","unstructured":"JeggoMHWardleyRC. 1982. 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