{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T01:41:16Z","timestamp":1720316476016},"reference-count":30,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2014,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Atypical and classical scrapie-infected sheep brain tissue was monolaterally injected into the tonsils of lambs to investigate their role as a prion entry point. We first detected classical PrP\n            <jats:sup>Sc<\/jats:sup>\n            within the inoculated tonsil and in the ipsilateral retropharyngeal lymph node at 3 months postinoculation (p.i.). At 7 months p.i., PrP\n            <jats:sup>Sc<\/jats:sup>\n            colonized other lymphoid tissues bilaterally, including ileal Peyer's patches. The earliest PrP\n            <jats:sup>Sc<\/jats:sup>\n            deposition within the brain was ipsilaterally observed at 9 months p.i. in the substantia reticularis of the medulla oblongata. At 12 months p.i., PrP\n            <jats:sup>Sc<\/jats:sup>\n            deposition was present bilaterally in the nucleus parasympathicus nervi vagi, as well as in the intermediolateral cell column of the thoracolumbar spinal cord. No PrP\n            <jats:sup>Sc<\/jats:sup>\n            was detected in the lambs inoculated with atypical scrapie. These findings suggest that neuroinvasion may naturally occur from the tonsil after a widespread prion replication within the lymphoid tissues during classical scrapie only, thus mimicking the pathogenesis after oral ingestion.\n          <\/jats:p>","DOI":"10.1128\/jvi.02750-13","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T02:53:07Z","timestamp":1383792787000},"page":"1065-1070","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Role of Palatine Tonsils as a Prion Entry Site in Classical and Atypical Experimental Sheep Scrapie"],"prefix":"10.1128","volume":"88","author":[{"given":"Maria G.","family":"Cancedda","sequence":"first","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale of Sardinia, Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Di Guardo","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi, Facolt\u00e0 di Medicina Veterinaria, Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Chiocchetti","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi, Dipartimento di Scienze Mediche Veterinarie, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Demontis","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale of Sardinia, Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Marruchella","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi, Facolt\u00e0 di Medicina Veterinaria, Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Sorteni","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi, Dipartimento di Scienze Mediche Veterinarie, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Maestrale","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale of Sardinia, Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfio","family":"Lai","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale of Sardinia, Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciriaco","family":"Ligios","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale of Sardinia, Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13363"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-12-3115"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002402"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002449"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.5.1228-1231.1996"},{"key":"e_1_3_2_7_2","first-page":"57","article-title":"Pathogenesis of natural scrapie in sheep","volume":"16","author":"van Keulen LJ","year":"2000","unstructured":"van KeulenLJSchreuderBEVromansMELangeveldJPSmitsMA. 2000. 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