{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T05:29:57Z","timestamp":1775971797901,"version":"3.50.1"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2015,2,15]],"date-time":"2015-02-15T00:00:00Z","timestamp":1423958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In 49 patients with known Ebola virus disease outcomes during the ongoing outbreak in Sierra Leone, 13 were coinfected with the immunomodulatory pegivirus GB virus C (GBV-C). Fifty-three percent of these GBV-C\n            <jats:sup>+<\/jats:sup>\n            patients survived; in contrast, only 22% of GBV-C\n            <jats:sup>\u2212<\/jats:sup>\n            patients survived. Both survival and GBV-C status were associated with age, with older patients having lower survival rates and intermediate-age patients (21 to 45 years) having the highest rate of GBV-C infection. Understanding the separate and combined effects of GBV-C and age on Ebola virus survival may lead to new treatment and prevention strategies, perhaps through age-related pathways of immune activation.\n          <\/jats:p>","DOI":"10.1128\/jvi.02752-14","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T05:27:20Z","timestamp":1417670840000},"page":"2425-2429","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":66,"title":["GB Virus C Coinfections in West African Ebola Patients"],"prefix":"10.1128","volume":"89","author":[{"given":"Michael","family":"Lauck","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Wisconsin National Primate Research Center, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam L.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Wisconsin National Primate Research Center, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian G.","family":"Andersen","sequence":"additional","affiliation":[{"name":"The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony L.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, Madison, Wisconsin, USA"},{"name":"Department of Pathobiological Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pardis C.","family":"Sabeti","sequence":"additional","affiliation":[{"name":"The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Wisconsin National Primate Research Center, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Ebola response roadmap\u2014situation report update","author":"World Health Organization","year":"2014","unstructured":"World Health Organization. 14 November 2014. 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