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This inoculation resulted in a systemic disease with clinical and morphological features mirroring those in fatal human Lassa infection: fever, weight loss, high viremia and viral RNA load in tissues, elevated liver enzymes, and severe morbidity between days 15 and 20. The most prominent histopathology findings included multifocal hepatic necrosis with mild inflammation and hepatocyte proliferation, lymphoid depletion, and interstitial nephritis. Cellular aggregates in regions of hepatocellular necrosis were largely composed of HAM56-positive macrophages, devoid of CD3-positive and CD20-positive cells, and characterized by marked reductions in the intensity of HLA-DP, DQ, DR staining. A marked reduction in the major histocompatibility complex class II expression was also observed in the lymph nodes. Immunophenotypic alterations in spleen included reductions in overall numbers of CD20-positive and CD3-positive cells and the disruption of lymphoid follicular architecture. These findings identify the common marmoset as an appropriate model of human Lassa fever and present the first experimental evidence that replication of Lassa virus in tissues is associated with alterations that would be expected to impair adaptive immunity.<\/jats:p>","DOI":"10.1128\/jvi.02876-06","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T00:24:31Z","timestamp":1175732671000},"page":"6482-6490","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":106,"title":["Lassa Virus Infection in Experimentally Infected Marmosets: Liver Pathology and Immunophenotypic Alterations in Target Tissues"],"prefix":"10.1128","volume":"81","author":[{"suffix":"Jr.","given":"Ricardo","family":"Carrion","sequence":"first","affiliation":[{"name":"Department of Virology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Brasky","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Mansfield","sequence":"additional","affiliation":[{"name":"New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Virology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Department of Virology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anysha","family":"Ticer","sequence":"additional","affiliation":[{"name":"Department of Virology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Lukashevich","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette","family":"Tardif","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Virology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.0909"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(88)90033-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890210109"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.02.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2861"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.18.2391"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.12.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1982.31.1038"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.02.038"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90767-7"},{"key":"e_1_3_2_12_2","first-page":"345","year":"1998","unstructured":"Davern, T., and B. 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