{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:49:02Z","timestamp":1774975742615,"version":"3.50.1"},"reference-count":58,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2014,2,15]],"date-time":"2014-02-15T00:00:00Z","timestamp":1392422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2014,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Machupo virus (MACV) is the etiological agent of Bolivian hemorrhagic fever (BHF), a reemerging and neglected tropical disease associated with high mortality. The prototypical strain of MACV, Carvallo, was isolated from a human patient in 1963, but minimal\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            characterization has been reported. To this end, we utilized reverse genetics to rescue a pathogenic MACV from cloned cDNAs. The recombinant MACV (rMACV) had\n            <jats:italic>in vitro<\/jats:italic>\n            growth properties similar to those of the parental MACV. Both viruses caused similar disease development in alpha\/beta and gamma interferon receptor knockout mice, including neurological disease development and high mortality. In addition, we have identified a novel murine model with mortality and neurological disease similar to BHF disease reported in humans and nonhuman primates.\n          <\/jats:p>","DOI":"10.1128\/jvi.02925-13","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T04:25:20Z","timestamp":1385612720000},"page":"1914-1923","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Rescue of a Recombinant Machupo Virus from Cloned cDNAs and\n            <i>In Vivo<\/i>\n            Characterization in Interferon (\u03b1\u03b2\/\u03b3) Receptor Double Knockout Mice"],"prefix":"10.1128","volume":"88","author":[{"given":"Michael","family":"Patterson","sequence":"first","affiliation":[{"name":"Galveston National Laboratory, Department of Pathology, Sealy Vaccine Center, University of Texas Medical Branch, Galveston, Texas, 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