{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:10:50Z","timestamp":1790543450584,"version":"4.1.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind MERS-CoV. Site-directed mutagenesis of amino acids variable in ferret DPP4 thus revealed the functional human DPP4 virus binding site. Adenosine deaminase (ADA), a DPP4 binding protein, competed for virus binding, acting as a natural antagonist for MERS-CoV infection.<\/jats:p>","DOI":"10.1128\/jvi.02935-13","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T22:15:58Z","timestamp":1384985758000},"page":"1834-1838","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":150,"title":["Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus"],"prefix":"10.1128","volume":"88","author":[{"given":"V. Stalin","family":"Raj","sequence":"first","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia L.","family":"Smits","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"},{"name":"Viroclinics Biosciences, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette B.","family":"Provacia","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M. A.","family":"van den Brand","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidewij","family":"Wiersma","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner J. D.","family":"Ouwendijk","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo M.","family":"Bestebroer","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique I.","family":"Spronken","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"van Amerongen","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J. M.","family":"Rottier","sequence":"additional","affiliation":[{"name":"Virology Division, Department of Infectious Diseases &amp; Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron A. M.","family":"Fouchier","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berend Jan","family":"Bosch","sequence":"additional","affiliation":[{"name":"Virology Division, Department of Infectious Diseases &amp; Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert D.M.E.","family":"Osterhaus","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"},{"name":"Viroclinics Biosciences, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart L.","family":"Haagmans","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00473-12"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211721"},{"key":"e_1_3_2_4_2","volume-title":"Middle East respiratory syndrome coronavirus (MERS-CoV)\u2014update 2013\/10\/04","author":"World Health Organization","year":"2013","unstructured":"World Health Organization. 2013. Middle East respiratory syndrome coronavirus (MERS-CoV)\u2014update 2013\/10\/04. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1910.130946"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1911.131172"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit123"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069127"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.007823"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/425915a"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1078\/0171-9335-00302"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.108"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12328"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.92"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI02448-13"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405001200"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01277-13"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33080-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501050102"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02935-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02935-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T10:45:10Z","timestamp":1646477110000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02935-13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1128\/JVI.02935-13"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02935-13","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"2013-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}