{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:29:32Z","timestamp":1758709772748},"reference-count":14,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The varicella-zoster virus (VZV) ORF61 protein is necessary for normal replication\n            <jats:italic>in vitro<\/jats:italic>\n            and virulence in human skin xenografts in the severe combined immunodeficiency mouse model\n            <jats:italic>in vivo<\/jats:italic>\n            . These experiments identify a hydrophobic domain that mediates ORF61 self-interaction. While not needed to inhibit host cell defenses, disruption of this domain (residues 250 to 320) severely impairs VZV growth, transactivation of the immediate early 63 and glycoprotein E genes, and the pathogenesis of VZV skin infection\n            <jats:italic>in vivo<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/jvi.02963-12","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T01:35:12Z","timestamp":1358991312000},"page":"4075-4079","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Identification of a Hydrophobic Domain in Varicella-Zoster Virus ORF61 Necessary for ORF61 Self-Interaction, Viral Replication, and Skin Pathogenesis"],"prefix":"10.1128","volume":"87","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Rajamani","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin","family":"Sommer","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh","family":"Zerboni","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M.","family":"Arvin","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"2","volume-title":"Fields virology","author":"Cohen JI","year":"2007","unstructured":"CohenJI StrausSE ArvinAM . 2007. 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