{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:37:17Z","timestamp":1790303837527,"version":"4.1.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2013,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Measles virus (MV) isolates from patients with subacute sclerosing panencephalitis (SSPE) differ from wild-type MV virologically. However, few animal models have reported viruses with characteristics of the SSPE virus. The MV Edmonston strain was inoculated into the subarachnoid space of nude mice. All nude mice displayed weight loss and required euthanasia, with a mean survival duration of 73.2 days. The viral load in the brain was 4- to 400-fold higher than the inoculated load, and brain infection was confirmed by immunostaining. Gene sequencing of the viruses revealed that amino acid mutations occurred more frequently in matrix proteins. The most common mutation was a uridine-to-cytosine transition. The virus exhibited lower free virus particle formation ability than the Edmonston strain. When nude mice were challenged with 2 \u00d7 10<jats:sup>2<\/jats:sup>PFU of the brain-derived virus, the mean survival duration was 34.7 days, which was significantly shorter than that of the mice challenged with 4 \u00d7 10<jats:sup>4<\/jats:sup>PFU of the Edmonston strain (<jats:italic>P<\/jats:italic>&lt; 0.01). This study indicated that MV in a nude mouse model of persistent infection exhibited characteristics of the SSPE virus. This model may prove useful in elucidating the pathogenic mechanism of SSPE and developing potential therapeutics.<\/jats:p>","DOI":"10.1128\/jvi.03117-12","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T01:35:12Z","timestamp":1358991312000},"page":"4170-4175","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Characteristics of Viruses Derived from Nude Mice with Persistent Measles Virus Infection"],"prefix":"10.1128","volume":"87","author":[{"given":"Yusaku","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Fukushima Medical University, Fukusjima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1551","volume-title":"Fields virology","author":"Griffin D","year":"2007","unstructured":"GriffinD. 2007. Measles virus, p 1551\u20131585. In KnipeDM . (ed), Fields virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.","edition":"5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.04.005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82221-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002240"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.4.1908-1918.2000"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.02.033"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03717.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym207"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2222\/jsv.53.15"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1182"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90020-C"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.12.5464-5468.1989"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1984.tb00731.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051376"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81838-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.9.4399-4401.2001"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1982.tb00270.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-006-0035-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03150250078007"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/150.3.340"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811436250"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.1795-1801.1999"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.5.822"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30343"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000106940.95749.8E"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/13550280701455383"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.4049\/jimmunol.144.6.2394","article-title":"The predominance of CD8+ T cells after infection with measles virus suggests a role for CD8+ class I MHC-restricted cytotoxic T lymphocytes (CTL) in recovery from measles. Clonal analyses of human CD8+ class I MHC-restricted CTL","volume":"144","author":"van Binnendijk RS","year":"1990","unstructured":"van BinnendijkRS PoelenMC KuijpersKC OsterhausAD UytdehaagFG. 1990. The predominance of CD8+ T cells after infection with measles virus suggests a role for CD8+ class I MHC-restricted cytotoxic T lymphocytes (CTL) in recovery from measles. Clonal analyses of human CD8+ class I MHC-restricted CTL. J. Immunol. 144:2394\u20132399.","journal-title":"J. Immunol."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.2.480"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/318499"},{"key":"e_1_3_2_31_2","first-page":"63","article-title":"Mutations and A\/I hypermutations in measles virus persistent infections","volume":"176","author":"Cattaneo R","year":"1992","unstructured":"CattaneoR BilleterMA. 1992. Mutations and A\/I hypermutations in measles virus persistent infections. Curr. Top. Microbiol. Immunol. 176:63\u201374.","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90048-7"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.10.10.5586-5590.1990"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90234-1"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.8.5425-5432.1994"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3109\/13550289509111013"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.14.3899"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01075-10"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.03117-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.03117-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T22:45:01Z","timestamp":1687992301000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.03117-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,15]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,4,15]]}},"alternative-id":["10.1128\/JVI.03117-12"],"URL":"https:\/\/doi.org\/10.1128\/jvi.03117-12","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,15]]},"assertion":[{"value":"2012-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}