{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:56:06Z","timestamp":1793307366062,"version":"4.5.0"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Viruses in the\n            <jats:named-content content-type=\"genus-species\">Ebolavirus<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Marburgvirus<\/jats:named-content>\n            genera (family\n            <jats:named-content content-type=\"genus-species\">Filoviridae<\/jats:named-content>\n            ) have been associated with large outbreaks of hemorrhagic fever in human and nonhuman primates. The first documented cases occurred in primates over 45 years ago, but the amount of virus genetic diversity detected within bat populations, which have recently been identified as potential reservoir hosts, suggests that the filoviruses are much older. Here, detailed Bayesian coalescent phylogenetic analyses are performed on 97 whole-genome sequences, 55 of which are newly reported, to comprehensively examine molecular evolutionary rates and estimate dates of common ancestry for viruses within the family\n            <jats:named-content content-type=\"genus-species\">Filoviridae<\/jats:named-content>\n            . Molecular evolutionary rates for viruses belonging to different species range from 0.46 \u00d7 10\n            <jats:sup>\u22124<\/jats:sup>\n            nucleotide substitutions\/site\/year for\n            <jats:named-content content-type=\"genus-species\">Sudan ebolavirus<\/jats:named-content>\n            to 8.21 \u00d7 10\n            <jats:sup>\u22124<\/jats:sup>\n            nucleotide substitutions\/site\/year for\n            <jats:named-content content-type=\"genus-species\">Reston ebolavirus<\/jats:named-content>\n            . Most recent common ancestry can be traced back only within the last 50 years for\n            <jats:named-content content-type=\"genus-species\">Reston ebolavirus<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Zaire ebolavirus<\/jats:named-content>\n            species and suggests that viruses within these species may have undergone recent genetic bottlenecks. Viruses within\n            <jats:named-content content-type=\"genus-species\">Marburg marburgvirus<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Sudan ebolavirus<\/jats:named-content>\n            species can be traced back further and share most recent common ancestors approximately 700 and 850 years before the present, respectively. Examination of the whole family suggests that members of the\n            <jats:named-content content-type=\"genus-species\">Filoviridae<\/jats:named-content>\n            , including the recently described Lloviu virus, shared a most recent common ancestor approximately 10,000 years ago. These data will be valuable for understanding the evolution of filoviruses in the context of natural history as new reservoir hosts are identified and, further, for determining mechanisms of emergence, pathogenicity, and the ongoing threat to public health.\n          <\/jats:p>","DOI":"10.1128\/jvi.03118-12","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T10:12:43Z","timestamp":1355998363000},"page":"2608-2616","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":150,"title":["Molecular Evolution of Viruses of the Family Filoviridae Based on 97 Whole-Genome Sequences"],"prefix":"10.1128","volume":"87","author":[{"given":"Serena A.","family":"Carroll","sequence":"first","affiliation":[{"name":"Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Towner","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara K.","family":"Sealy","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"McMullan","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina L.","family":"Khristova","sequence":"additional","affiliation":[{"name":"Biotechnology Core Facility Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicity J.","family":"Burt","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases, Special Pathogens Unit, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Swanepoel","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases, Special Pathogens Unit, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre E.","family":"Rollin","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart T.","family":"Nichol","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"1409","volume-title":"Fields virology.","author":"Sanchez A","year":"2007","unstructured":"SanchezA GeisbertTW FeldmannH. 2007. Filoviridae: Marburg and Ebola Viruses, p 1409\u20131448. In KnipeDM HowleyPM (ed), Fields virology. Lippincott Williams and Wilkins, Philadelphia, PA."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-010-0814-x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00069-06"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002304"},{"key":"e_1_3_3_6_2","first-page":"997","article-title":"Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread","volume":"61","author":"Baron RC","year":"1983","unstructured":"BaronRC McCormickJB ZubeirOA. 1983. Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread. Bull. World Health Organ. 61:997\u20131003.","journal-title":"Bull. 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SeaView and Phylo_win, two graphic tools for sequence alignment and molecular phylogeny. Comput. Appl. Biosci. 12:543\u2013548.","journal-title":"Comput. Appl. Biosci."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-7-214"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040088"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a003872"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6086.541"},{"key":"e_1_3_3_42_2","first-page":"271","article-title":"Ebola haemorrhagic fever in Zaire, 1976","volume":"56","author":"Johnson KM","year":"1978","unstructured":"JohnsonKM. 1978. Ebola haemorrhagic fever in Zaire, 1976. Bull. World Health Organ. 56:271\u2013293.","journal-title":"Bull. 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World Health Organization Geneva Switzerland. http:\/\/www.who.int\/csr\/resources\/publications\/HSE_EPR_2009_2.pdf."},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir300"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp244"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.03118-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.03118-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:36:17Z","timestamp":1646494577000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.03118-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1128\/JVI.03118-12"],"URL":"https:\/\/doi.org\/10.1128\/jvi.03118-12","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"2012-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}