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By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T cells, but not the expression of inhibitory molecules on those T cells or their ligands in the liver, predicts the outcome of acute infection.<\/jats:p>","DOI":"10.1128\/jvi.03122-12","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T02:58:00Z","timestamp":1360205880000},"page":"4772-4777","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["The Frequency of CD127\n            <sup>+<\/sup>\n            Hepatitis C Virus (HCV)-Specific T Cells but Not the Expression of Exhaustion Markers Predicts the Outcome of Acute HCV Infection"],"prefix":"10.1128","volume":"87","author":[{"given":"Eui-Cheol","family":"Shin","sequence":"first","affiliation":[{"name":"Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA"},{"name":"Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelina","family":"Nascimbeni","sequence":"additional","affiliation":[{"name":"Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Major","sequence":"additional","affiliation":[{"name":"Laboratory of Hepatitis Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Caggiari","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Pharmacology Unit, CRO Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano (PN), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valli","family":"de Re","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Pharmacology Unit, CRO Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano (PN), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Feinstone","sequence":"additional","affiliation":[{"name":"Laboratory of Hepatitis Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles M.","family":"Rice","sequence":"additional","affiliation":[{"name":"Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Rehermann","sequence":"additional","affiliation":[{"name":"Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.044"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.9.1499"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01581-07"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.1395"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21242"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20856"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.3447"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420515"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000947"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7860-7867.2005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02474-07"},{"key":"e_1_3_2_13_2","first-page":"1437","article-title":"Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection","volume":"38","author":"Sugimoto K","year":"2003","unstructured":"SugimotoK IkedaF StadanlickJ NunesFA AlterHJ ChangKM. 2003. 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