{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:03:29Z","timestamp":1791561809806,"version":"4.3.4"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Varicella-zoster virus (VZV) is responsible for both varicella (chickenpox) and herpes zoster (shingles). During varicella, the virus establishes latency within the sensory ganglia and can reactivate to cause herpes zoster, but the immune responses that occur in ganglia during herpes zoster have not previously been defined. We examined ganglia obtained from individuals who, at the time of death, had active herpes zoster. Ganglia innervating the site of the cutaneous herpes zoster rash showed evidence of necrosis, secondary to vasculitis, or localized hemorrhage. Despite this, there was limited evidence of VZV antigen expression, although a large inflammatory infiltrate was observed. Characterization of the infiltrating T cells showed a large number of infiltrating CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and cytolytic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Many of the infiltrating T cells were closely associated with neurons within the reactivated ganglia, yet there was little evidence of T cell-induced neuronal apoptosis. Notably, an upregulation in the expression of major histocompatibility complex class I (MHC-I) and MHC-II molecules was observed on satellite glial cells, implying these cells play an active role in directing the immune response during herpes zoster. This is the first detailed characterization of the interaction between T cells and neuronal cells within ganglia obtained from patients suffering herpes zoster at the time of death and provides evidence that CD4\n                    <jats:sup>+<\/jats:sup>\n                    and cytolytic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses play an important role in controlling VZV replication in ganglia during active herpes zoster.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>IMPORTANCE<\/jats:bold>\n                    VZV is responsible for both varicella (chickenpox) and herpes zoster (shingles). During varicella, the virus establishes a life-long dormant infection within the sensory ganglia and can reawaken to cause herpes zoster, but the immune responses that occur in ganglia during herpes zoster have not previously been defined. We examined ganglia obtained from individuals who, at the time of death, had active herpes zoster. We found that specific T cell subsets are likely to play an important role in controlling VZV replication in ganglia during active herpes zoster.\n                  <\/jats:p>","DOI":"10.1128\/jvi.03445-13","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T02:25:34Z","timestamp":1387419934000},"page":"2704-2716","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":127,"title":["Analysis of T Cell Responses during Active Varicella-Zoster Virus Reactivation in Human Ganglia"],"prefix":"10.1128","volume":"88","author":[{"given":"Megan","family":"Steain","sequence":"first","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, New South Wales, Australia"},{"name":"Centre for Virus Research, Westmead Millennium Institute, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, New South Wales, Australia"},{"name":"Centre for Virus Research, Westmead Millennium Institute, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, NSW Health Pathology, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony L.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Centre for Virus Research, Westmead Millennium Institute, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Slobedman","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, New South Wales, Australia"},{"name":"Centre for Virus Research, Westmead Millennium Institute, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Abendroth","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, New South Wales, Australia"},{"name":"Centre for Virus Research, Westmead Millennium Institute, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60074-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1982.00340150091017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2011.01167.x"},{"key":"e_1_3_2_5_2","first-page":"S13","article-title":"Herpes zoster pathogenesis and cell-mediated immunity and immunosenescence","volume":"109","author":"Oxman MN","year":"2009","unstructured":"OxmanMN. 2009. 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