{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T09:27:33Z","timestamp":1780824453486,"version":"3.54.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T00:00:00Z","timestamp":1429056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2015,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The development of treatments for Ebola virus disease (EVD) has been hampered by the lack of small-animal models that mimick human disease. Here we show that mice with transplanted human hematopoetic stem cells reproduce features typical of EVD. Infection with Ebola virus was associated with viremia, cell damage, liver steatosis, signs of hemorrhage, and high lethality. Our study provides a small-animal model with human components for the development of EVD therapies.<\/jats:p>","DOI":"10.1128\/jvi.03546-14","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T06:52:40Z","timestamp":1423723960000},"page":"4700-4704","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Ebola Virus Disease in Mice with Transplanted Human Hematopoietic Stem Cells"],"prefix":"10.1128","volume":"89","author":[{"given":"Anja","family":"L\u00fcdtke","sequence":"first","affiliation":[{"name":"Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany"},{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, 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