{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:06:48Z","timestamp":1793189208756,"version":"4.5.0"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"16","license":[{"start":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T00:00:00Z","timestamp":1376524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2013,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Rabies virus (RABV) maintenance in bats is not well understood. Big brown bats (\n            <jats:named-content content-type=\"genus-species\">Eptesicus fuscus<\/jats:named-content>\n            ), little brown bats (\n            <jats:named-content content-type=\"genus-species\">Myotis lucifugus<\/jats:named-content>\n            ), and Mexican free-tailed bats (\n            <jats:named-content content-type=\"genus-species\">Tadarida brasiliensis<\/jats:named-content>\n            ) are the most common bats species in the United States. These colonial bat species also have the most frequent contact with humans and domestic animals. However, the silver-haired bat (\n            <jats:named-content content-type=\"genus-species\">Lasionycteris noctivagans<\/jats:named-content>\n            ) RABV is associated with the majority of human rabies virus infections in the United States and Canada. This is of interest because silver-haired bats are more solitary bats with infrequent human interaction. Our goal was to determine the likelihood of a colonial bat species becoming infected with and transmitting a heterologous RABV. To ascertain the potential of heterologous RABV infection in colonial bat species, little brown bats were inoculated with a homologous RABV or one of two heterologous RABVs. Additionally, to determine if the route of exposure influenced the disease process, bats were inoculated either intramuscularly (i.m.) or subcutaneously (s.c.) with a homologous or heterologous RABV. Our results demonstrate that intramuscular inoculation results in a more rapid progression of disease onset, whereas the incubation time in bats inoculated s.c. is significantly longer. Additionally, cross protection was not consistently achieved in bats previously inoculated with a heterologous RABV following a challenge with a homologous RABV 6 months later. Finally, bats that developed rabies following s.c. inoculation were significantly more likely to shed virus in their saliva and demonstrated increased viral dissemination. In summary, bats inoculated via the s.c. route are more likely to shed virus, thus increasing the likelihood of transmission.\n          <\/jats:p>","DOI":"10.1128\/jvi.03554-12","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:16:37Z","timestamp":1370477797000},"page":"9008-9015","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Susceptibility and Pathogenesis of Little Brown Bats (Myotis lucifugus) to Heterologous and Homologous Rabies Viruses"],"prefix":"10.1128","volume":"87","author":[{"given":"April D.","family":"Davis","sequence":"first","affiliation":[{"name":"Rabies Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie A.","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Rabies Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Pouliott","sequence":"additional","affiliation":[{"name":"Rabies Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon, M. D.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Albany, State University of New York, Albany, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Rudd","sequence":"additional","affiliation":[{"name":"Rabies Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"114","volume-title":"Rabies","author":"Childs JE","year":"2002","unstructured":"ChildsJE. 2002. Epidemiology, p 114\u2013149. In JacksonAC WunnerWH (ed), Rabies. Academic Press, San Diego, CA."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80710-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188836"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002786"},{"key":"e_1_3_2_6_2","first-page":"119","volume-title":"Bats, revised edition","author":"Fenton B","year":"2001","unstructured":"FentonB. 2001. And now some bats, p 119\u2013148. In Bats, revised edition. Checkmark Books, New York, NY."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2011.0839"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/342387"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.11.5653"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01964-06"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.011510-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2011.0674"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.25.8.1456-1458.1987"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.11.2522-2528.1989"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-48.2.508"},{"issue":"1","key":"e_1_3_2_16_2","first-page":"1","article-title":"Human rabies prevention\u2014United States. 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Ph.D. dissertation. Colorado State University Fort Collins CO."},{"key":"e_1_3_2_23_2","unstructured":"RuddRJ. 8 August 2012 posting date. Rabies annual report. New York State Department of Health Rabies Laboratory Slingerlands NY. http:\/\/www.wadsworth.org\/rabies\/annualsum.htm."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064808"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/117.1.82"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.83688-0"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-005-0785-0"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.237.12.1395"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387040-7.00003-2"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/290542a0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/290590a0"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-65-6-1091"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.03554-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.03554-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:57:45Z","timestamp":1646488665000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.03554-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,15]]},"references-count":31,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2013,8,15]]}},"alternative-id":["10.1128\/JVI.03554-12"],"URL":"https:\/\/doi.org\/10.1128\/jvi.03554-12","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,15]]},"assertion":[{"value":"2012-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}