{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:09:18Z","timestamp":1768565358677,"version":"3.49.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"22","license":[{"start":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T00:00:00Z","timestamp":1321315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2011,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In sub-Saharan Africa, HIV-1 infection frequently occurs in the context of other coinfecting pathogens, most importantly,\n            <jats:named-content content-type=\"genus-species\">Mycobacterium tuberculosis<\/jats:named-content>\n            and malaria parasites. The consequences are often devastating, resulting in enhanced morbidity and mortality. Due to the large number of confounding factors influencing pathogenesis in coinfected people, we sought to develop a nonhuman primate model of simian immunodeficiency virus (SIV)-malaria coinfection. In sub-Saharan Africa,\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            is the most common malaria parasite and is responsible for most malaria-induced deaths. The simian malaria parasite\n            <jats:named-content content-type=\"genus-species\">Plasmodium fragile<\/jats:named-content>\n            can induce clinical symptoms, including cerebral malaria in rhesus macaques, that resemble those of\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            infection in humans. Thus, based on the well-characterized rhesus macaque model of SIV infection, this study reports the development of a novel rhesus macaque SIV-\n            <jats:named-content content-type=\"genus-species\">P. fragile<\/jats:named-content>\n            coinfection model to study human HIV-\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            coinfection. Using this model, we show that coinfection is associated with an increased, although transient, risk of both HIV and malaria transmission. Specifically, SIV-\n            <jats:named-content content-type=\"genus-species\">P. fragile<\/jats:named-content>\n            coinfected macaques experienced an increase in SIV viremia that was temporarily associated with an increase in potential SIV target cells and systemic immune activation during acute parasitemia. Conversely, primary parasitemia in SIV-\n            <jats:named-content content-type=\"genus-species\">P. fragile<\/jats:named-content>\n            coinfected animals resulted in higher gametocytemia that subsequently translated into higher oocyst development in mosquitoes. To our knowledge, this is the first animal model able to recapitulate the increased transmission risk of both HIV and malaria in coinfected humans. Therefore, this model could serve as an essential tool to elucidate distinct immunological, virological, and\/or parasitological parameters underlying disease exacerbation in HIV-malaria coinfected people.\n          <\/jats:p>","DOI":"10.1128\/jvi.05644-11","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T06:13:06Z","timestamp":1316067186000},"page":"11655-11663","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Evidence for an Increased Risk of Transmission of Simian Immunodeficiency Virus and Malaria in a Rhesus Macaque Coinfection Model"],"prefix":"10.1128","volume":"85","author":[{"given":"Kristin A.","family":"Trott","sequence":"first","affiliation":[{"name":"California National Primate Research Center, University of California at Davis, County Road 98\/Hutchison Drive, Davis, California 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Y.","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California at Davis, One Shields Avenue, Davis, California 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Hudgens","sequence":"additional","affiliation":[{"name":"Center for AIDS Research, Lineberger Comprehensive Cancer Center, CB 7295, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295"},{"name":"Department of Biostatistics, McGavran-Greenberg Hall, CB 7420, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7420"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Fine","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, McGavran-Greenberg Hall, CB 7420, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7420"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelu K.","family":"Mfalila","sequence":"additional","affiliation":[{"name":"Center for AIDS Research, Lineberger Comprehensive Cancer Center, CB 7295, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross P.","family":"Tarara","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California at Davis, County Road 98\/Hutchison Drive, Davis, California 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Collins","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Center for Global Health, Division of Parasitic Diseases and Malaria, 1600 Clifton Road, Atlanta, Georgia 30333"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Center for Global Health, Division of Parasitic Diseases and Malaria, 1600 Clifton Road, Atlanta, Georgia 30333"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Luckhart","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California at Davis, One Shields Avenue, Davis, California 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Abel","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, 120 Mason Farm Rd., CB 7042, Chapel Hill, North Carolina 27599-7042"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02240-05"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.19.12164-12172.2005"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132338"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761992000700074"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199906180-00023"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2516(98)80083-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6958"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/27.2.296"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1979.28.591"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2005.00128.x"},{"key":"e_1_3_3_12_2","unstructured":"CoatneyG. 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