{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T10:21:38Z","timestamp":1717582898170},"reference-count":38,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Varicella-zoster virus (VZV) is a member of the alphaherpesvirus family and the causative agent of chickenpox and shingles. To determine the utility of cynomolgus macaques (<jats:named-content content-type=\"genus-species\">Macaca fascicularis<\/jats:named-content>) as a nonhuman primate model to evaluate VZV-based simian immunodeficiency virus\/human immunodeficiency virus (SIV\/HIV) vaccines, we experimentally inoculated 10 animals with the parental Oka (Oka-P) strain of VZV derived from MeWo or Telo-RF cells. VZV DNA could be detected in the lungs as late as 4 days postinfection, with replicating virus detected by shell vial culture assay in one case. Infection did not result in any overt clinical symptoms but was characterized by humoral and cell-mediated immunity in a time frame and at a magnitude similar to those observed following VZV vaccination in humans. The cell line source of VZV inoculum influenced both the magnitude and polyfunctionality of cell-mediated immunity. Animals mounted a vigorous anamnestic antibody response following a second inoculation 12 weeks later. Inoculations resulted in transient increases in CD4<jats:sup>+<\/jats:sup>T-cell activation and proliferation, as well as a sustained increase in CD4<jats:sup>+<\/jats:sup>T cells coexpressing CCR5 and \u03b14\u03b27 integrin. In contrast to previous failed attempts to successfully utilize attenuated VZV-Oka as an SIV vaccine vector in rhesus macaques due to suboptimal infectivity and cellular immunogenicity, the ability to infect cynomolgus macaques with Oka-P VZV should provide a valuable tool for evaluating VZV-vectored SIV\/HIV vaccines.<\/jats:p>","DOI":"10.1128\/jvi.06264-11","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T06:01:50Z","timestamp":1326952910000},"page":"3626-3634","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Experimental Infection of Cynomolgus Macaques (Macaca fascicularis) with Human Varicella-Zoster Virus"],"prefix":"10.1128","volume":"86","author":[{"given":"David O.","family":"Willer","sequence":"first","affiliation":[{"name":"Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Clinical Sciences Division, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aruna P. N.","family":"Ambagala","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Clinical Sciences Division, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Pilon","sequence":"additional","affiliation":[{"name":"National HIV and Retrovirology Laboratories, National Microbiology Laboratory, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn","family":"Fournier","sequence":"additional","affiliation":[{"name":"Scientific Services Division, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Brooks","sequence":"additional","affiliation":[{"name":"National Laboratory for HIV Genetics, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Sandstrom","sequence":"additional","affiliation":[{"name":"National HIV and Retrovirology Laboratories, National Microbiology Laboratory, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly S.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Clinical Sciences Division, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Immunology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1566"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000060317","volume-title":"Varicella-zoster virus. 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