{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:52:49Z","timestamp":1791251569361,"version":"4.1.0"},"reference-count":71,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although O-mannosylated dystroglycan is a receptor for Lassa virus, a causative agent of Lassa fever, recent findings suggest the existence of an alternative receptor(s). Here we identified four molecules as receptors for Lassa virus: Axl and Tyro3, from the TAM family, and dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and liver and lymph node sinusoidal endothelial calcium-dependent lectin (LSECtin), from the C-type lectin family. These molecules enhanced the binding of Lassa virus to cells and mediated infection independently of dystroglycan. Axl- or Tyro3-mediated infection required intracellular signaling via the tyrosine kinase activity of Axl or Tyro3, whereas DC-SIGN- or LSECtin-mediated infection and binding were dependent on a specific carbohydrate and on ions. The identification of these four molecules as Lassa virus receptors advances our understanding of Lassa virus cell entry.<\/jats:p>","DOI":"10.1128\/jvi.06451-11","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:10:07Z","timestamp":1323303007000},"page":"2067-2078","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":161,"title":["Identification of Cell Surface Molecules Involved in Dystroglycan-Independent Lassa Virus Cell Entry"],"prefix":"10.1128","volume":"86","author":[{"given":"Masayuki","family":"Shimojima","sequence":"first","affiliation":[{"name":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Str\u00f6her","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ebihara","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kawaoka","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan"},{"name":"ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.2.599-613.2002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.13.6841-6844.2002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2861"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1059"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02814"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000024429.73158.DE"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201123"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.04.002"},{"key":"e_1_3_2_10_2","first-page":"1791","volume-title":"Fields virology","author":"Buchmeier MJ","year":"2001","unstructured":"BuchmeierMJ de la TorreJ-C PetersCJ. 2001. Arenaviridae: the viruses and their replication, p 1791\u20131827. In KnipeDM (ed), Fields virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia.","edition":"5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2079"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110656"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.4.2156"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10380"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/08977199409001055"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(72)90268-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90035-W"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.4.809"},{"key":"e_1_3_2_19_2","first-page":"645","volume-title":"Virus taxonomy","author":"Feldmann H","year":"2004","unstructured":"FeldmannH. 2004. Family Filoviridae, p 645\u2013653. In FauquetCM MayoMA ManiloffJ DesselbergerU BallLA (ed), Virus taxonomy, 8th ed. Elsevier\/Academic Press, London, United Kingdom.","edition":"8"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890260204"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-1-1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.10.5458-5465.2004"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01186.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.06.026"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408360490497456"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81708-0"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.12.6134-6142.2004"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01278-09"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.10.1651"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/355696a0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.14297-14308.2005"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.2008\/004721-0"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1983.32.829"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.9.6706-6713.1997"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.14282-14296.2005"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.10.5979-5987.2005"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200104103"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)00002-X"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311227200"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199912)59:4<552::AID-JMV21>3.0.CO;2-A"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1086\/320722"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.2797"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652407780831601"},{"key":"e_1_3_2_44_2","first-page":"75","article-title":"Lassa fever","volume":"262","author":"McCormick JB","year":"2002","unstructured":"McCormickJB Fisher-HochSP. 2002. Lassa fever. Curr. Top. Microbiol. Immunol. 262:75\u2013109.","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198601023140104"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1986.35.401"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00837"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.185.4147.263"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301206"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.03.012"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200404000-00020"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90434-D"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.598"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706292200"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02574-06"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2010_2368"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01607-08"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(98)00114-7"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600912"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207340200"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1086\/520594"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01157-06"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.6.2943-2947.2004"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14764"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.09.005"},{"key":"e_1_3_2_66_2","first-page":"349","article-title":"Pathologic and virologic study of fatal Lassa fever in man","volume":"107","author":"Walker DH","year":"1982","unstructured":"WalkerDH. 1982. Pathologic and virologic study of fatal Lassa fever in man. Am. J. Pathol. 107:349\u2013356.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.89.3.674"},{"key":"e_1_3_2_68_2","first-page":"535","article-title":"The pathology of human Lassa fever","volume":"52","author":"Winn WC","year":"1975","unstructured":"WinnWCJr WalkerDH. 1975. The pathology of human Lassa fever. Bull. World Health Organ. 52:535\u2013545.","journal-title":"Bull. World Health Organ."},{"key":"e_1_3_2_69_2","first-page":"599","article-title":"Lassa virus hepatitis. Observations on a fatal case from the 1972 Sierra Leone epidemic","volume":"99","author":"Winn WC","year":"1975","unstructured":"WinnWCJr MonathTP MurphyFA WhitfieldSG. 1975. Lassa virus hepatitis. Observations on a fatal case from the 1972 Sierra Leone epidemic. Arch. Pathol. 99:599\u2013604.","journal-title":"Arch. Pathol."},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2004.03.020"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/bp0200705"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00070-3"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.06451-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.06451-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T10:19:14Z","timestamp":1646475554000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.06451-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,15]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,2,15]]}},"alternative-id":["10.1128\/JVI.06451-11"],"URL":"https:\/\/doi.org\/10.1128\/jvi.06451-11","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,15]]},"assertion":[{"value":"2011-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}