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To address these questions, ovine fetuses at 35 days of gestation were inoculated<jats:italic>in utero<\/jats:italic>with Cache Valley virus and euthanized at 7, 10, 14, 21, and 28 days postinfection. On postmortem examination, arthrogryposis and oligohydramnios were observed in some infected fetuses. Morphological studies showed necrosis in the central nervous system and skeletal muscle of infected fetuses evaluated after 7 to 14 days postinfection, and hydrocephalus, micromyelia, and muscular loss were observed in infected fetuses after 21 to 28 days postinfection. Using immunohistochemistry and<jats:italic>in situ<\/jats:italic>hybridization, intense Cache Valley virus antigen and RNA staining was detected in the brain, spinal cord, skeletal muscle, and, to a lesser degree, in fetal membranes and other tissues of infected fetuses. Viral antigen and RNA staining decreased in targeted and infected tissues with the progression of the infection.<\/jats:p>","DOI":"10.1128\/jvi.06858-11","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T02:41:17Z","timestamp":1330569677000},"page":"4793-4800","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Identification of the Target Cells and Sequence of Infection during Experimental Infection of Ovine Fetuses with Cache Valley Virus"],"prefix":"10.1128","volume":"86","author":[{"given":"Aline","family":"Rodrigues Hoffmann","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christabel Jane","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Texas A&amp;M University, College Station, Texas, USA"},{"name":"Department of Veterinary Integrative Biosciences, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Wilcox","family":"Varner","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"de la Concha-Bermejillo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Texas A&amp;M University, College Station, Texas, USA"},{"name":"Texas Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Marchand","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Ambrus","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Francis","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(02)00022-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1958.sp005911"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61418-1"},{"key":"e_1_3_2_5_2","first-page":"27","article-title":"Bunyaviridae\u2014natural history","volume":"169","author":"Beaty BJ","year":"1991","unstructured":"BeatyBJ CalisherCH. 1991. 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