{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:57:09Z","timestamp":1791356229623,"version":"4.3.1"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2012,4,15]],"date-time":"2012-04-15T00:00:00Z","timestamp":1334448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2012,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            HIV elite controllers (EC) are a rare group of HIV-infected patients who are able to maintain undetectable viral loads during a long period of time in the absence of antiretroviral treatment. Adaptive immunity and host genetic factors, although implicated, do not entirely explain this phenomenon. On the other hand, plasmacytoid dendritic cells (pDCs) are the principal type I interferon (IFN) producers in response to viral infection, and it is unknown whether pDCs are involved in the control of HIV infection in EC. In our study, we analyzed peripheral pDC levels and IFN-\u03b1 production by peripheral blood mononuclear cells (PBMCs) in EC compared to other groups of HIV-infected patients, the ability of pDCs to reduce HIV production\n            <jats:italic>in vitro<\/jats:italic>\n            , and the mechanisms potentially involved. We showed preserved pDC counts and IFN-\u03b1 production in EC. We also observed a higher capacity of pDCs from EC to reduce HIV production and to induce T cell apoptosis, whereas pDCs from viremic patients barely responded without previous Toll-like receptor 9 (TLR-9) stimulus. The preserved functionality of pDCs from EC to reduce viral production may be one of the mechanisms involved in the control of HIV viremia in these subjects. These results demonstrate the importance of innate immunity in HIV pathogenesis, and an understanding of pDC mechanisms would be helpful for the design of new therapies.\n          <\/jats:p>","DOI":"10.1128\/jvi.07114-11","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T11:39:37Z","timestamp":1328787577000},"page":"4245-4252","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":77,"title":["Plasmacytoid Dendritic Cells Reduce HIV Production in Elite Controllers"],"prefix":"10.1128","volume":"86","author":[{"given":"K.","family":"Machmach","sequence":"first","affiliation":[{"name":"Laboratory of Immunovirology, Biomedicine Institute of Seville (IBIS), Infectious Diseases Service, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Biochemistry Department, Virgen del Roc\u00edo University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leal","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Biomedicine Institute of Seville (IBIS), Infectious Diseases Service, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Biochemistry Department, Virgen del Roc\u00edo University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gras","sequence":"additional","affiliation":[{"name":"CNRS UMR 8147, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Viciana","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Biomedicine Institute of Seville (IBIS), Infectious Diseases Service, Virgen del Roc\u00edo University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Genebat","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Biomedicine Institute of Seville (IBIS), Infectious Diseases Service, Virgen del Roc\u00edo University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Franco","sequence":"additional","affiliation":[{"name":"Centro Regional de Transfusiones Sangu\u00edneas Sevilla\/Huelva y Banco de Tejidos, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Boufassa","sequence":"additional","affiliation":[{"name":"INSERM U1012, Bic\u00eatre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Lambotte","sequence":"additional","affiliation":[{"name":"INSERM U1012, Bic\u00eatre"},{"name":"AP-HP, Department of Internal Medicine and Infectious Diseases, Bic\u00eatre Hospital, Bic\u00eatre"},{"name":"Universit\u00e9 Paris-Sud, U1012, Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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