{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:22:48Z","timestamp":1773757368104,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>Defective Epstein-Barr virus (EBV) has a deleted and rearranged genome (termed het DNA) that disrupts latency and induces standard EBV to replicate in vitro. We used the polymerase chain reaction to detect, in 2 of 10 patient samples, the junction of abnormally juxtaposed EBV DNA fragments BamHI W and Z, a genomic rearrangement responsible for the biologic activity of het DNA. By sequence analysis, the junction in wild-type defective DNA appears to be similar but not identical to the recombination in the DNA of laboratory strain P3HR-1. The presence of this marker for het DNA in the epithelial lesions of two patients suggests a role for defective EBV in a human pathologic process.<\/jats:p>","DOI":"10.1128\/jvi.64.1.397-400.1990","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T15:41:53Z","timestamp":1578325313000},"page":"397-400","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Defective viral DNA in Epstein-Barr virus-associated oral hairy leukoplakia"],"prefix":"10.1128","volume":"64","author":[{"given":"D F","family":"Patton","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology, St Jude Children's Research Hospital, Memphis, Tennessee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Shirley","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, St Jude Children's Research Hospital, Memphis, Tennessee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Raab-Traub","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, St Jude Children's Research Hospital, Memphis, Tennessee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Resnick","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, St Jude Children's Research Hospital, Memphis, Tennessee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J W","family":"Sixbey","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, St Jude Children's Research Hospital, Memphis, Tennessee."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.64.1.397-400.1990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.64.1.397-400.1990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T23:49:19Z","timestamp":1646437759000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.64.1.397-400.1990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1128\/jvi.64.1.397-400.1990"],"URL":"https:\/\/doi.org\/10.1128\/jvi.64.1.397-400.1990","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]},"assertion":[{"value":"1990-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}