{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:35:07Z","timestamp":1770726907672,"version":"3.49.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>The role of B7 binding CD28 in the regulation of T- and B-cell responses against viral antigens was assessed in transgenic mice expressing soluble CTLA4-Hgamma1 (CTLA4-Ig tg mice) that blocks B7-CD28 interactions. The results indicate that transgenic soluble CTLA4 does not significantly alter cytotoxic T-cell responses against replicating lymphocytic choriomeningitis virus (LCMV) or vaccinia virus but drastically impairs the induction of cytotoxic T-cell responses against abortively replicating vesicular stomatitis virus (VSV). While the T-independent neutralizing immunoglobulin M (IgM) responses were within normal ranges, the switch to IgG was reduced 4- to 16-fold after immunization with abortively replicating VSV and more than 30-fold after immunization with an inert VSV glycoprotein antigen in transgenic mice. IgG antibody responses to LCMV, as detected by enzyme-linked immunosorbent assay and by neutralizing action, were reduced about 3- to 20-fold and more than 50-fold, respectively. These results suggest that responses in CTLA4-Ig tg mice are mounted according to their independence of T help. While immune responses to nonreplicating or poorly replicating antigens are in general most dependent on T help and B7-CD28 interactions, they are most impaired in CTLA4-Ig tg mice. The results of the present experiments also indicate that highly replicating viruses, because of greater quantities of available antigens and by inducing as-yet-undefined factors and\/or cell surface changes, are capable of compensating for the decrease in T help caused by the blocking effects of soluble CTLA4.<\/jats:p>","DOI":"10.1128\/jvi.71.3.1802-1807.1997","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T22:02:29Z","timestamp":1578348149000},"page":"1802-1807","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Antiviral immune responses in CTLA4 transgenic mice"],"prefix":"10.1128","volume":"71","author":[{"given":"C","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Institute of Experimental Immunology, University Hospital, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Seiler","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University Hospital, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lane","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University Hospital, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"Zinkernagel","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University Hospital, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.71.3.1802-1807.1997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.71.3.1802-1807.1997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:23:05Z","timestamp":1646486585000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.71.3.1802-1807.1997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["10.1128\/jvi.71.3.1802-1807.1997"],"URL":"https:\/\/doi.org\/10.1128\/jvi.71.3.1802-1807.1997","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]},"assertion":[{"value":"1997-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}