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Most of the HIV IC that bound to B cells were not internalized but remained on the cell surface and were gradually released over 72 h. Cell-bound HIV IC were highly infectious for T cells while virus released by cultured B cells was only slightly infectious. Removal of HIV IC from the B-cell surface by protease treatment reduced the infection of T cells to near-background levels, indicating that infectious virus remained on the B-cell surface. These studies show that B lymphocytes can carry and transfer infectious HIV IC to T cells and thus suggest a novel mode of infection of T cells in lymphoid tissue that could be important for pathogenesis during HIV infection.<\/jats:p>","DOI":"10.1128\/jvi.74.1.552-555.2000","type":"journal-article","created":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T21:08:16Z","timestamp":1240520896000},"page":"552-555","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["Immune Complexes Containing Human Immunodeficiency Virus Type 1 Primary Isolates Bind to Lymphoid Tissue B Lymphocytes and Are Infectious for T Lymphocytes"],"prefix":"10.1128","volume":"74","author":[{"given":"Jocelyn J.","family":"Jakubik","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Immunology\/Microbiology, Rush University, Chicago, Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Saifuddin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Immunology\/Microbiology, Rush University, Chicago, Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Takefman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Immunology\/Microbiology, Rush University, Chicago, Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory T.","family":"Spear","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Immunology\/Microbiology, Rush University, Chicago, Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02786455"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.19.10018"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb00968.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0250441"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.5.3603-3607.1999"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5373.96"},{"key":"e_1_3_2_8_2","first-page":"2055","article-title":"Human dendritic reticulum cells of lymphoid follicles: their antigenic profile and their identification as multinucleated giant cells","volume":"178","author":"Gerdes J.","year":"1993","unstructured":"Gerdes J. 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