{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:12:32Z","timestamp":1790622752437,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"20","license":[{"start":{"date-parts":[[2000,10,15]],"date-time":"2000-10-15T00:00:00Z","timestamp":971568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2000,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Postexposure prophylaxis (PEP) after intravaginal exposure to human immunodeficiency virus (HIV) was investigated using the HIV type 2 (HIV-2)\/pig-tailed macaque transmission model. PEP for 28 days with the reverse transcriptase inhibitor (\n            <jats:italic>R<\/jats:italic>\n            )-9-(2-phosphonylmethoxypropyl)adenine (PMPA; tenofovir) was initiated 12 to 72 h following HIV-2 exposure. Systemic infection was not evident in the 12- and 36-h groups, as defined by plasma viremia, cell-associated provirus, antibody responses, and lymph node virus. Breakthrough infection in the 72-h group was detected at week 16 post-virus exposure. These results demonstrate for the first time using a vaginal transmission model that early intervention after high-risk sexual exposures may prevent infection.\n          <\/jats:p>","DOI":"10.1128\/jvi.74.20.9771-9775.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:53Z","timestamp":1027763753000},"page":"9771-9775","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":180,"title":["Efficacy of Postexposure Prophylaxis after Intravaginal Exposure of Pig-Tailed Macaques to a Human-Derived Retrovirus (Human Immunodeficiency Virus Type 2)"],"prefix":"10.1128","volume":"74","author":[{"given":"Ron A.","family":"Otten","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of AIDS, STD, and TB Laboratory Research1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn K.","family":"Smith","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Division of HIV\/AIDS Prevention, Surveillance, and Epidemiology, National Center for HIV, STD, and TB Prevention,2 Centers for Disease Control and Prevention, Atlanta, Georgia 30333, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra R.","family":"Adams","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of AIDS, STD, and TB Laboratory Research1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Pullium","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of AIDS, STD, and TB Laboratory Research1"},{"name":"<!--label omitted: 3-->Division of Animal Resources, Emory University, Atlanta, Georgia 303323"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie","family":"Jackson","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->and Scientific Resources Program,4 National Center for Infectious Diseases, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn N.","family":"Kim","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of AIDS, STD, and TB Laboratory Research1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Jaffe","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of AIDS, STD, and TB Laboratory Research1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Janssen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Division of HIV\/AIDS Prevention, Surveillance, and Epidemiology, National Center for HIV, STD, and TB Prevention,2 Centers for Disease Control and Prevention, Atlanta, Georgia 30333, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sal","family":"Butera","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of AIDS, STD, and TB Laboratory Research1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Folks","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of AIDS, STD, and TB Laboratory Research1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00059-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199702000-00004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711203372101"},{"key":"e_1_3_2_5_2","first-page":"929","article-title":"Case control study of HIV seroconversation in health-care workers after percutaneous exposure to HIV-infected blood\u2014France, United Kingdom, and United States, January 1988\u2013August 1994","volume":"44","author":"Centers for Disease Control and Prevention","year":"1995","unstructured":"Centers for Disease Control and Prevention Case control study of HIV seroconversation in health-care workers after percutaneous exposure to HIV-infected blood\u2014France, United Kingdom, and United States, January 1988\u2013August 1994.Morb. 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