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We demonstrate that PGE<jats:sub>2<\/jats:sub>upregulates the HTLV-1 long terminal repeat promoter through the protein kinase A pathway, induces replication of HTLV-1 in peripheral blood mononuclear cells (PBMC) derived from asymptomatic carriers, and enhances transmission of HTLV-1 to cord blood mononuclear cells (CBMC). Furthermore, HTLV-1 Tax transactivates a promoter for cyclooxygenase 2, a PG synthetase, and induces PGE<jats:sub>2<\/jats:sub>expression in PBMC or CBMC. Thus, HTLV-1 interacts with and benefits from PGs, constituents of its own vehicle for transmission.<\/jats:p>","DOI":"10.1128\/jvi.75.1.192-198.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:53Z","timestamp":1027763753000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Reciprocal Interactions between Human T-Lymphotropic Virus Type 1 and Prostaglandins: Implications for Viral Transmission"],"prefix":"10.1128","volume":"75","author":[{"given":"Masako","family":"Moriuchi","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Inoue","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Pharmacology, National Cardiovascular Center Research Institute, Osaka,2 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Moriuchi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences,1 and"},{"name":"<!--label omitted: 3-->Department of Pediatrics, Nagasaki University School of Medicine,3 Nagasaki, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.8.2128.2128"},{"key":"e_1_3_2_3_2","unstructured":"Bydgeman M. 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