{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:24:49Z","timestamp":1761611089244},"reference-count":37,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>A key event in virus-induced inflammation (leukocyte extravasation through the endothelium) is the local activation of endothelial cells, as indicated by the expression of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. In order to identify triggers of inflammation in adenovirus infection, we inoculated respiratory and ocular epithelial cells with adenovirus type 37 (Ad37), a human pathogen associated with keratoconjunctivitis as well as urogenital and respiratory infections. Fluids from virus-infected epithelial cells activated ICAM-1 (and to a lesser extent, VCAM-1) expression on cultured human umbilical vein endothelial cells. Blocking studies with anticytokine antibodies implicated interleukin-1\u03b1 (IL-1\u03b1) as the epithelial cell-derived factor which activated endothelial cell ICAM-1 expression. The results thus identify epithelial cell-derived IL-1\u03b1 as a potentially important activator of endothelial cells in Ad37-induced inflammation.<\/jats:p>","DOI":"10.1128\/jvi.76.1.427-431.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:53Z","timestamp":1027763753000},"page":"427-431","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Interleukin-1\u03b1 Released from Epithelial Cells after Adenovirus Type 37 Infection Activates Intercellular Adhesion Molecule 1 Expression on Human Vascular Endothelial Cells"],"prefix":"10.1128","volume":"76","author":[{"given":"Cheng-Hsien","family":"Chang","sequence":"first","affiliation":[{"name":"Departments of Microbiology &amp; Immunology"},{"name":"Department of Ophthalmology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Departments of Microbiology &amp; Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Issekutz","sequence":"additional","affiliation":[{"name":"Departments of Microbiology &amp; Immunology"},{"name":"Pathology"},{"name":"Pediatrics Dalhousie University, Halifax B3H 4H7, Nova Scotia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May","family":"Griffith","sequence":"additional","affiliation":[{"name":"University of Ottawa Eye Institute, Ottawa Hospital-General Campus, Ottawa, Ontario K1H 8L6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuei-Hsiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Anderson","sequence":"additional","affiliation":[{"name":"Departments of Microbiology &amp; Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb00275.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.12.2.241-252.1973"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.6.4226-4232.1997"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.8269"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200104000-00011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890070204"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.12.3940-3945.1999"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830189809043005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60363-2"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5447.2169"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890450417"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050300"},{"key":"e_1_3_2_14_2","first-page":"600","volume":"79","year":"1993","unstructured":"Issekutz, A. 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