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Chimeric particles produced by transient transfection of this chimeric provirus were infectious for murine cells, such as NIH 3T3 fibroblasts, lymphoid EL4 cells, and primary CD4\n            <jats:sup>+<\/jats:sup>\n            T lymphocytes, whereas HTLV-1 particles were not. The infectivity of chimeric particles increased 10 times when the R peptide located at the carboxy terminus of the MuLV envelope glycoprotein was deleted. Primary murine CD4\n            <jats:sup>+<\/jats:sup>\n            T lymphocytes, infected by the \u0394R chimeric virus, released particles that could spread the infection to other naive murine lymphoid cells. This chimeric virus, with the Mo-MuLV envelope glycoprotein and the replication characteristics of HTLV-1, should be useful in studying the pathogenesis of HTLV-1 in a mouse model.\n          <\/jats:p>","DOI":"10.1128\/jvi.76.15.7883-7889.2002","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:07:23Z","timestamp":1027897643000},"page":"7883-7889","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["A Chimeric Human T-Cell Lymphotropic Virus Type 1 with the Envelope Glycoprotein of Moloney Murine Leukemia Virus Is Infectious for Murine Cells"],"prefix":"10.1128","volume":"76","author":[{"given":"Fre\u0301de\u0301ric","family":"Delebecque","sequence":"first","affiliation":[{"name":"Unite\u0301 des Virus Lents, URA 1930 CNRS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Pramberger","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Virus Lents, URA 1930 CNRS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Pre\u0301vost","sequence":"additional","affiliation":[{"name":"Plateforme de Microscopie Electronique, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Brahic","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Virus Lents, URA 1930 CNRS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fre\u0301de\u0301ric","family":"Tangy","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Virus Lents, URA 1930 CNRS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90134-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0889-1605(86)90049-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/229564b0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.1.259-266.1997"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.7.4149-4157.1995"},{"key":"e_1_3_2_7_2","first-page":"1907","volume":"9","year":"1995","unstructured":"Derse, D., J. 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