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Using the EBV-positive Burkitt's lymphoma line P3HR1-c16, which lacks LMP1 during latency and which can readily be activated into virus-productive lytic cycle, we found that LMP1 inhibits lytic cycle induction via the transcription factor NF-\u03baB. In addition, LMP1 inhibits lytic cycle progress via two distinct NF-\u03baB-independent mechanisms: one involving the cytosolic C-terminal activating regions and the other involving the transmembrane region of LMP1. These findings indicate that in B cells EBV self-limits its lytic cycle via three distinct LMP1-mediated mechanisms.<\/jats:p>","DOI":"10.1128\/jvi.77.8.5000-5007.2003","type":"journal-article","created":{"date-parts":[[2003,3,27]],"date-time":"2003-03-27T17:23:27Z","timestamp":1048785807000},"page":"5000-5007","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Latent Membrane Protein 1 Inhibits Epstein-Barr Virus Lytic Cycle Induction and Progress via Different Mechanisms"],"prefix":"10.1128","volume":"77","author":[{"given":"Stuart","family":"Prince","sequence":"first","affiliation":[{"name":"Section of Infection and Immunity, University of Wales College of Medicine, Cardiff CF14 4XX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinead","family":"Keating","sequence":"additional","affiliation":[{"name":"Section of Infection and Immunity, University of Wales College of Medicine, Cardiff CF14 4XX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceri","family":"Fielding","sequence":"additional","affiliation":[{"name":"Section of Infection and Immunity, University of Wales College of Medicine, Cardiff CF14 4XX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brennan","sequence":"additional","affiliation":[{"name":"Section of Infection and Immunity, University of Wales College of Medicine, Cardiff CF14 4XX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike","family":"Floettmann","sequence":"additional","affiliation":[{"name":"Section of Infection and Immunity, University of Wales College of Medicine, Cardiff CF14 4XX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rowe","sequence":"additional","affiliation":[{"name":"Section of Infection and Immunity, University of Wales College of Medicine, Cardiff CF14 4XX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.5.2388-2399.2001"},{"key":"e_1_3_2_3_2","first-page":"437","volume":"99","year":"2002","unstructured":"Adler, B., E. 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