{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:02:27Z","timestamp":1791306147091,"version":"4.3.1"},"reference-count":65,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus identified and causes both adult T-cell leukemia\/lymphoma and tropical spastic paraparesis\/HTLV-1-associated myelopathy, among other disorders. In vitro, HTLV-1 has an extremely broad host cell tropism in that it is capable of infecting most mammalian cell types, although at the same time viral titers remain relatively low. Despite years of study, only recently has a bona fide candidate cellular receptor, glucose transporter 1 (glut-1), been identified. Although glut-1 was shown to bind specifically to the ectodomain of HTLV-1 and HTLV-2 envelope glycoproteins, which was reversible with small interfering RNA directed against glut-1, cellular susceptibility to HTLV upon expression of glut-1 was not established. Here we show that expression of glut-1 in relatively resistant MDBK cells conferred increased susceptibility to both HTLV-1- and HTLV-2-pseudotyped particles. glut-1 also markedly increased syncytium formation in MDBK cells after exposure to HTLV-1. Another assay also demonstrated HTLV-1 envelope-cell fusion in the presence of glut-1. Taken together, these results provide additional evidence that glut-1 is a receptor for HTLV.<\/jats:p>","DOI":"10.1128\/jvi.79.7.4150-4158.2005","type":"journal-article","created":{"date-parts":[[2005,3,15]],"date-time":"2005-03-15T02:41:44Z","timestamp":1110854504000},"page":"4150-4158","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Expression of Glucose Transporter 1 Confers Susceptibility to Human T-Cell Leukemia Virus Envelope-Mediated Fusion"],"prefix":"10.1128","volume":"79","author":[{"given":"Ayse Kubra","family":"Coskun","sequence":"first","affiliation":[{"name":"Department of Molecular Virology and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology"},{"name":"Center for Cell and Gene Therapy and Department of Medicine, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.3.406"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300302"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03340080026022"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050596"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6316502"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910360107"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215549904700806"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(99)00173-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/326714a0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(03)00058-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70225-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2536196100"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290606"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.23.7588"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2003.11.012"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.23.7591"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080115"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830200205"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.5.1653"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.38.3.906-915.1981"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202063260604"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C901002199"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.19.6202"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910330602"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00881-X"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2681"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09460-4"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/104303402760128522"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.6.1171"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.12.3587"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-7-555"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320310"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(86)94086-7"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2277"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1984.tb00083.x"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210203"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.11.5270-5276.1990"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)38267-X"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07872.x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/294268a0"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6760397"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb27196.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6089348"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-188"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097931"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90230-O"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201246"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.4.628"},{"key":"e_1_3_2_54_2","first-page":"12","volume":"5","year":"1992","unstructured":"Stuver, S. O., N. Tachibana, A. Okayama, F. Romano, T. Yokota, and N. Mueller. 1992. Determinants of HTLV-1 seroprevalence in Miyazaki Prefecture, Japan: a cross-sectional study. J. Acquir. Immune Defic. Syndr.5:12-18.","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.10.7322-7326.1996"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.7.5781-5788.1998"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910400605"},{"key":"e_1_3_2_58_2","first-page":"893","volume":"73","year":"1982","unstructured":"Tajima, K., S. Tominaga, T. Suchi, T. Kawagoe, H. Komoda, Y. Hinuma, T. Oda, and K. Fujita. 1982. Epidemiological analysis of the distribution of antibody to adult T-cell leukemia-virus-associated antigen: possible horizontal transmission of adult T-cell leukemia virus. Gann73:893-901.","journal-title":"Gann"},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4049\/jimmunol.147.1.354","volume":"147","year":"1991","unstructured":"Tanaka, Y., L. Zeng, H. Shiraki, H. Shida, and H. Tozawa. 1991. Identification of a neutralization epitope on the envelope gp46 antigen of human T cell leukemia virus type I and induction of neutralizing antibody by peptide immunization. J. Immunol.147:354-360.","journal-title":"J. Immunol."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200009)16:3<224::AID-HUMU5>3.0.CO;2-P"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(84)90446-X"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80939-3"},{"key":"e_1_3_2_63_2","first-page":"235","volume":"115","year":"1985","unstructured":"Weiss, R. A., P. Clapham, K. Nagy, and H. Hoshino. 1985. Envelope properties of human T-cell leukemia viruses. Curr. Top Microbiol. Immunol.115:235-246.","journal-title":"Curr. Top Microbiol. Immunol."},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/302626a0"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910330606"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.79.7.4150-4158.2005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.79.7.4150-4158.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T16:54:28Z","timestamp":1683046468000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.79.7.4150-4158.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1128\/JVI.79.7.4150-4158.2005"],"URL":"https:\/\/doi.org\/10.1128\/jvi.79.7.4150-4158.2005","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"2004-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}