{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:05:56Z","timestamp":1781708756590,"version":"3.54.5"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Mumps virus (MuV) has been shown to antagonize the antiviral effects of interferon (IFN) through proteasome-mediated complete degradation of STAT1 by using the viral V protein (T. Kubota et al., Biochem. Biophys. Res. Commun. 283:255-259, 2001). However, we found that MuV could inhibit IFN signaling and the generation of a subsequent antiviral state long before the complete degradation of cellular STAT1 in infected cells. In MuV-infected cells, nuclear translocation and phosphorylation of STAT1 and STAT2 tyrosine residue (Y) at 701 and 689, respectively, by IFN-\u03b2 were significantly inhibited but the phosphorylation of Jak1 and Tyk2 was not inhibited. The transiently expressed MuV V protein also inhibited IFN-\u03b2-induced Y<jats:sup>701<\/jats:sup>-STAT1 and Y<jats:sup>689<\/jats:sup>-STAT2 phosphorylation, suggesting that the V protein could block IFN-\u03b2-induced signal transduction without the aid of other viral components. Finally, a substitution of an alanine residue in place of a cysteine residue in the C-terminal V-unique region known to be required for STAT1 degradation and inhibition of anti-IFN signaling resulted in the loss of V protein function to inhibit the Y<jats:sup>701<\/jats:sup>-STAT1 and Y<jats:sup>689<\/jats:sup>-STAT2 phosphorylation.<\/jats:p>","DOI":"10.1128\/jvi.79.7.4451-4459.2005","type":"journal-article","created":{"date-parts":[[2005,3,15]],"date-time":"2005-03-15T02:41:44Z","timestamp":1110854504000},"page":"4451-4459","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Mumps Virus V Protein Antagonizes Interferon without the Complete Degradation of STAT1"],"prefix":"10.1128","volume":"79","author":[{"given":"Toru","family":"Kubota","sequence":"first","affiliation":[{"name":"Department of Virology III, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yokosawa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Virology III, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Virology III, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.5.2159-2167.2002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.22.11379-11386.2002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9771"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1302"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.9.5127"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.4.3125-3133.1999"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.12.9928-9933.1999"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(99)00114-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2001.tb01315.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1151"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1738"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.16.8676-8685.2003"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206738"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102030200"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.8.3802-3810.2001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.14.7443-7454.2004"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.0864"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4764"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.12676-12682.2002"},{"key":"e_1_3_2_21_2","first-page":"1305","year":"2001","unstructured":"Lamb, R. A., and D. Kolakofsky. 2001. Paramyxoviridae: the viruses and their replication, p. 1305-1340. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed. Lippincott, Williams and Wilkins Press, Philadelphia, Pa.","journal-title":"Fields virology, 4th ed."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm909"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9317"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890050102"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-64-7-1457"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.4049\/jimmunol.162.10.6107","volume":"162","year":"1999","unstructured":"Miller, D. M., Y. Zhang, B. M. Rahill, W. J. Waldam, and D. D. Sedmak. 1999. Human cytomegalovirus inhibits IFN-\u03b1-stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-\u03b1 signal transduction. J. Immunol.162:6107-6113.","journal-title":"J. Immunol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00226-6"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2335168100"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.19.9165-9176.2001"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1509"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.13.7635-7644.2003"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.0856"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.9.4190-4198.2002"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.2.1501-1511.2003"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1737"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.22.11476-11483.2002"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.21.11842-11845.2003"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(03)00537-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.11.5633-5641.2004"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90400-L"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00528-3"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1773"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.11.6385-6393.2003"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100087200"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.2989"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.20.10109-10121.2002"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050434"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.12683-12690.2002"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.0941"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(02)00026-0"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.7.3363-3370.2001"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.79.7.4451-4459.2005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.79.7.4451-4459.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T16:54:12Z","timestamp":1683046452000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.79.7.4451-4459.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1128\/JVI.79.7.4451-4459.2005"],"URL":"https:\/\/doi.org\/10.1128\/jvi.79.7.4451-4459.2005","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"2004-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}